On-line measurement of the absolute humidity of air, breath and liquid headspace samples by selected ion flow tube mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Patrik Spanel, David Smith

Abstract

We describe how selected ion flow tube mass spectrometry (SIFT-MS) can be used to determine the absolute humidity of air, breath and liquid headspace samples. This involves the determination of the relative count rates of the H3O+ ions and those H3O+.(H2O)(1,2,3) hydrate ions that inevitably form in the helium carrier gas when humid samples are being analysed by SIFT-MS using H3O+ precursor ions. This requires an understanding of the kinetics of hydrated hydronium ion formation, the involvement of mass discrimination in the analytical quadrupole mass spectrometer and the decreased diffusive loss of the heavier hydrates along the flow tube. Thus, we show that the humidity of breath and liquid headspace samples, typically at the few percent level, can be directly obtained on-line to the SIFT-MS instrument along with the concentrations of trace gases, which are present at much lower levels. We emphasise the value of parallel humidity measurements in ensuring good real-time sampling of breath and liquid headspace and the value of such measurements to trace gas analysis using SIFT-MS.

References

Feb 1, 1992·Rapid Communications in Mass Spectrometry : RCM·J O Metzger, E Bruns-Weller
Jan 1, 1996·Rapid Communications in Mass Spectrometry : RCM·D Smith, P Spanel
Nov 1, 1996·Medical & Biological Engineering & Computing·P Spanĕl, D Smith
May 27, 1999·Rapid Communications in Mass Spectrometry : RCM·D SmithJ B Elder
Oct 3, 2000·Rapid Communications in Mass Spectrometry : RCM·P Spanĕl, D Smith

❮ Previous
Next ❯

Citations

Jun 25, 2014·Metabolites·Célia Lourenço, Claire Turner
Aug 14, 2013·Rapid Communications in Mass Spectrometry : RCM·Kseniya DryahinaDavid Smith
Jun 28, 2016·Sensors·Julian W Gardner, Timothy A Vincent
Nov 5, 2002·Rapid Communications in Mass Spectrometry : RCM·Patrik SpanelDavid Smith
Aug 28, 2001·Journal of Mass Spectrometry : JMS
Sep 1, 2007·Journal of Breath Research·David SmithPatrik Spaněl
Sep 1, 2007·Journal of Breath Research·Patrik SpanělDavid Smith
Dec 1, 2007·Journal of Breath Research·Patrik SpanelDavid Smith
Sep 1, 2008·Journal of Breath Research·Jens HerbigArmin Hansel
Aug 21, 2013·Journal of Breath Research·Klaus WinklerIngrid Kohl
Apr 1, 2014·Journal of Breath Research·David SmithJonathan Beauchamp
Nov 23, 2019·Rapid Communications in Mass Spectrometry : RCM·Regina Brůhová MichalčíkováPatrik Španěl
Jan 14, 2003·Annals of Medicine·Philip G Bowler
Apr 1, 2014·Journal of Breath Research·Lukas BregyRenato Zenobi
Nov 20, 2015·Journal of Breath Research·Patrik ŠpanělDavid Smith
Mar 9, 2013·Journal of Breath Research·Paweł MochalskiBogusław Buszewski
Sep 6, 2014·Journal of Breath Research·Jens Herbig, Jonathan Beauchamp
Nov 30, 2013·Journal of Breath Research·David SmithWarren Lenney
May 18, 2016·Journal of Breath Research·David SmithPatrik Španěl
Jul 22, 2010·Mass Spectrometry Reviews·Patrik Spaněl, David Smith
Apr 13, 2019·Analytical and Bioanalytical Chemistry·Kristýna SovováPatrik Španěl
Mar 1, 2014·European Journal of Mass Spectrometry·Patrik Spanel, David Smith
Oct 31, 2020·Rapid Communications in Mass Spectrometry : RCM·Gitte SlingersGudrun Koppen
Jul 21, 2012·Analytical Chemistry·Amlendu PrabhakarNongjian Tao
Oct 9, 2019·Chemical Reviews·Tobias BrudererRenato Zenobi
Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Patrik ŠpanělDavid Smith

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.