On locating multiple interacting quantitative trait loci in intercross designs.

Genetics
Andreas BaierlAndreas Futschik

Abstract

A modified version (mBIC) of the Bayesian Information Criterion (BIC) has been previously proposed for backcross designs to locate multiple interacting quantitative trait loci. In this article, we extend the method to intercross designs. We also propose two modifications of the mBIC. First we investigate a two-stage procedure in the spirit of empirical Bayes methods involving an adaptive (i.e., data-based) choice of the penalty. The purpose of the second modification is to increase the power of detecting epistasis effects at loci where main effects have already been detected. We investigate the proposed methods by computer simulations under a wide range of realistic genetic models, with nonequidistant marker spacings and missing data. In the case of large intermarker distances we use imputations according to Haley and Knott regression to reduce the distance between searched positions to not more than 10 cM. Haley and Knott regression is also used to handle missing data. The simulation study as well as real data analyses demonstrates good properties of the proposed method of QTL detection.

References

Apr 1, 1994·Genetics·Z B Zeng
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z B Zeng
Jan 1, 1996·Genetics·R W Doerge, G A Churchill
Jul 2, 1999·Genetics·C H KaoR D Teasdale
Jan 5, 2001·Genetics·H P Piepho, H G Gauch
Feb 2, 2002·Nature Reviews. Genetics·Rebecca W Doerge
Mar 20, 2002·Genetics·Chen-Hung Kao, Zhao-Bang Zeng
Jun 5, 2002·Trends in Genetics : TIG·Mikko J Sillanpää, Jukka Corander
Jun 21, 2002·Genetical Research·Orjan Carlborg, Leif Andersson
Jun 21, 2002·Genetical Research·Nengjun Yi, Shizhong Xu
Jul 3, 2004·Genetics, Selection, Evolution : GSE·Akira Narita, Yoshiyuki Sasaki
Jul 22, 2004·Nature Reviews. Genetics·Orjan Carlborg, Chris S Haley
May 13, 1983·Science·S KirkpatrickM P Vecchi

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Citations

Nov 7, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Huihui LiJiankang Wang
Jul 9, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·B Emma Huang, Andrew W George
Nov 17, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Chris C SchönAlbrecht E Melchinger
Mar 26, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zehua Chen, Wenquan Cui
Jul 19, 2013·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Michael StangeTobias Würschum
Mar 25, 2011·Genetics Research·Nengjun Yi
Oct 24, 2006·Respiratory Research·Alice M Wood, Robert A Stockley
May 24, 2014·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Rasha KalihThomas Miedaner
Feb 18, 2010·Computational Statistics & Data Analysis·Daniel Shriner, Nengjun Yi
Jun 22, 2010·Journal of the Science of Food and Agriculture·Josef PribylJana Pribylova
Jan 21, 2014·Journal of Statistical Computation and Simulation·Thuan NguyenJiming Jiang
Mar 23, 2017·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias WürschumHans Peter Maurer
May 23, 2007·Journal of Dairy Science·J Szyda, J Komisarek
Jan 15, 2014·Statistical Applications in Genetics and Molecular Biology·Magdalena MalinaMałgorzata Bogdan

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