On lung endothelial cell heterogeneity

Microvascular Research
Sarah Gebb, Troy Stevens

Abstract

Heterogeneity in endothelial cell structure and function among vascular beds has been recognized for decades. However, recent findings have resolved that endothelial cells possess a functional memory based upon where they are in a blood vessel or based upon where they are isolated from within the blood vessel. Functional memory has been identified using integrated in vivo and in vitro bioassays and, most recently, through molecular profiling experiments. Memory is attributed to the epigenetic modification of phenotype that occurs in response to site-specific, cell-environment interaction during vascular development. In the embryo, Notch signal transduction is required for proper large blood vessel formation and function, whereas vascular endothelial cell growth factor (VEGF) is required for many of the processes of early vascular development including vasculogenesis and large vessel formation. Both Notch and VEGF are expressed in the developing lung, and their roles in pulmonary vascular development likely parallel those in the systemic circulation. Thus, integrated molecular profiling and transgenic technology provide new tools to investigate the interplay between epigenetic and environmental modulation of cell phenotype that ...Continue Reading

References

Oct 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J G GarciaC E Patterson
May 1, 1997·American Journal of Respiratory Cell and Molecular Biology·D E deMelloL M Reid
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·M J AcarreguiJ M Snyder
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·R V StanG E Palade
Feb 5, 2000·American Journal of Respiratory Cell and Molecular Biology·S K SchachtnerH Scott Baldwin
Mar 8, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S A Gebb, J M Shannon
Nov 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A M HealyW V Cardoso
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L Taraseviciene-StewartR M Tuder
Feb 13, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y S NgP A D'Amore
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·H UyttendaeleJ Kitajewski
Feb 28, 2002·American Journal of Respiratory Cell and Molecular Biology·Susan M HallSheila G Haworth
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·M DasK R Stenmark
Jun 26, 2002·The Journal of Cell Biology·Donna L CioffiTroy Stevens
Aug 30, 2002·Molecular Human Reproduction·G C WestonP A W Rogers
Sep 21, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Darren B TaichmanH Scott Baldwin
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·J C Parker, S Yoshikawa
Nov 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simona PodgrabinskaMihaela Skobe
Jan 23, 2003·Annals of the New York Academy of Sciences·Olga BandmanBenjamin G Cocks
Jan 28, 2003·Cancer·Carlton R CooperKenneth J Pienta
Feb 13, 2003·Medical Hypotheses·S YamagishiY Inagaki
Apr 3, 2003·EMBO Reports·Jeroen van de PeppelFrank C P Holstege
Apr 12, 2003·Cell Biology International·Stephen M King
May 8, 2003·American Journal of Physiology. Cell Physiology·Baiteng ZhaoPhillip D Bowman
Sep 10, 2003·Circulation·Mary M ChenThomas Quertermous
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jen-Tsan ChiPatrick O Brown
Dec 1, 1961·The Journal of Biophysical and Biochemical Cytology·G MAJNO, G E PALADE

❮ Previous
Next ❯

Citations

Mar 31, 2009·Clinical & Experimental Metastasis·Khair ElzarradAbu-Bakr Al-Mehdi
May 22, 2010·Seminars in Thrombosis and Hemostasis·Laura A Dyer, Cam Patterson
May 22, 2010·Seminars in Thrombosis and Hemostasis·Cristhiaan D OchoaTroy Stevens
Apr 20, 2010·Critical Care Medicine·Kevin LoweTroy Stevens
Feb 16, 2005·Annual Review of Physiology·Kurt R Stenmark, Steven H Abman
Oct 4, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cristhiaan D Ochoa, Troy Stevens
Aug 3, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Glenda Parra-BonillaTroy Stevens
Mar 8, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Szabolcs BertokMasao Takata
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rossana ChangLeif D Nelin
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·David F Meoli, R James White
Jul 30, 2005·American Journal of Respiratory and Critical Care Medicine·Diego F AlvarezMary I Townsley
Sep 14, 2010·American Journal of Respiratory and Critical Care Medicine·Serpil ErzurumTimothy M Moore
Dec 13, 2007·Proceedings of the American Thoracic Society·John GouldingTracy Hussell
Sep 2, 2008·Proceedings of the American Thoracic Society·Troy StevensKurt R Stenmark
Jul 10, 2014·Pulmonary Circulation·Patricia C Villalta, Mary I Townsley
Apr 1, 2009·Microvascular Research·Richard M Effros, James C Parker
Nov 26, 2008·Microvascular Research·Nutan Prasain, Troy Stevens
Aug 30, 2008·Vascular Pharmacology·Nikolaos A ManiatisStylianos E Orfanos
May 24, 2012·Biotechnology Progress·Annalaura ManciaAnne L Plant
Apr 23, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kimberly M ArnoldRobert B Wysolmerski
Nov 12, 2010·Cell Biology International·Karla LehleLeoni A Kunz-Schughart
Dec 22, 2009·Journal of Neuroscience Research·Jennifer A MacdonaldJoel S Pachter
Apr 21, 2006·Microvascular Research·Jarrod B AdkisonJames C Parker
Aug 2, 2005·Pharmacology & Therapeutics·Beata Wojciak-Stothard, Sheila G Haworth
Jul 9, 2009·Journal of the American College of Cardiology·Rubin M TuderSheila G Haworth
Jun 27, 2013·Experimental Cell Research·Kristen T Morin, Robert T Tranquillo
Aug 15, 2015·PloS One·April K ScruggsNatalie N Bauer
Mar 24, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Csaba Galambos, Daphne E deMello
Jan 19, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey D MarshallPatty J Lee
Aug 21, 2018·Pulmonary Circulation·Chun ZhouTroy Stevens
May 11, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Mervin C Yoder
Feb 22, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Aigul Moldobaeva, Elizabeth M Wagner
Dec 8, 2007·Journal of Cellular Physiology·Anna A BirukovaKonstantin G Birukov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.