On matching compliance between canine carotid arteries and polyurethane grafts

Artificial Organs
S Hsu, H Kambic

Abstract

Compliance mismatch between a host artery and an implanted graft has been suggested as a contributing factor to a small diameter graft failure. In this study, static compliance and dynamic compliance were defined and measured in vitro and in vivo for canine carotid arteries and 2 types of polyurethane grafts. Based on these compliance values, the circumferential modulus (E[theta]) and longitudinal modulus (Ez) were calculated. It was shown that grafts have constant moduli over a wide range of pressure while the moduli of carotid arteries increase significantly with increasing pressure (dynamic E[theta] from 0.20 to 1.32 MPa). Polyurethane grafts are nearly isotropic, with the modulus almost identical in each direction, while carotid arteries are anisotropic (E[theta]/Ez = 2-3). The dynamic moduli are generally higher than static values and are especially pronounced for arteries. Due to these different inherent characteristics, the compliance of a synthetic graft may match that of the host artery only in the circumferential direction and within a small pressure range. A stated limitation is therefore given for complete compliance matching. The results provide a rationale for identifying the degree of compliance match. These effo...Continue Reading

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Citations

Jul 27, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Paul C HoRichard W Nesto
Dec 2, 1999·Cell Transplantation·T Kobashi, T Matsuda
Aug 21, 2007·Biotechnology and Bioengineering·Liang ZhangShengshou Hu
Sep 16, 2017·Journal of Materials Science. Materials in Medicine·Yu Chieh TsengMing Long Yeh
May 8, 2003·Journal of Biomedical Materials Research. Part a·Hiromichi SonodaTakehisa Matsuda
Feb 17, 2005·Journal of Biomedical Materials Research. Part a·Takehisa MatsudaSatoru Kidoaki

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