On Modelling Minimal Disease Activity

Arthritis Care & Research
Christopher H JacksonVernon T Farewell

Abstract

To explore methods for statistical modelling of minimal disease activity (MDA) based on data from intermittent clinic visits. The analysis was based on a 2-state model. Comparisons were made between analyses based on "complete case" data from visits at which MDA status was known, and the use of hidden model methodology that incorporated information from visits at which only some MDA defining criteria could be established. Analyses were based on an observational psoriatic arthritis cohort. With data from 856 patients and 7,024 clinic visits, analysis was based on virtually all visits, although only 62.6% provided enough information to determine MDA status. Estimated mean times for an episode of MDA varied from 4.18 years to 3.10 years, with smaller estimates derived from the hidden 2-state model analysis. Over a 10-year period, the estimated expected times spent in MDA episodes of longer than 1 year was 3.90 to 4.22, and the probability of having such an MDA episode was estimated to be 0.85 to 0.91, with longer times and greater probabilities seen with the hidden 2-state model analysis. A 2-state model provides a useful framework for the analysis of MDA. Use of data from visits at which MDA status can not be determined provide m...Continue Reading

References

Jan 17, 2009·Annals of the Rheumatic Diseases·L C CoatesP S Helliwell
Jun 29, 2010·Biostatistics·Vernon T Farewell, Li Su

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Citations

Aug 29, 2018·Lifetime Data Analysis·Ardo van den Hout, Graciela Muniz-Terrera
Jan 21, 2019·Lifetime Data Analysis·Vernon T FarewellChristopher Jackson
Mar 9, 2020·Seminars in Arthritis and Rheumatism·Samar AlharbiDafna D Gladman

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Methods Mentioned

BETA
MDA
which

Software Mentioned

R
msm

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