On neural plasticity, new neurons and the postischemic milieu: an integrated view on experimental rehabilitation

Experimental Neurology
Mila KomitovaPeter S Eriksson

Abstract

This review discusses actual and potential contributors to functional improvement after stroke injuries. Topics that will be covered are neuronal re-organization and sprouting, neural stem/progenitor cell activation and neuronal replacement, as well as the neuronal milieu defined by glia, inflammatory cells and blood vessel supply. It is well established that different types of neuronal plasticity ultimately lead to post-stroke recovery. However, an untapped potential which only recently has started to be extensively explored is neuronal replacement through endogenous or exogenous resources. Major experimental efforts are needed to achieve progress in this burgeoning area. The review stresses the importance of applying neurodevelopmental principles as well as performing a characterization of the role of the postischemic milieu when studying adult brain neural stem/progenitor cells. Integrated and multifaceted experimentation, incorporating actual and possible poststroke function modulators, will be necessary in order to determine future strategies that will ultimately enable considerable progress in the field of neurorehabilitation.

References

Jan 1, 1979·The International Journal of Neuroscience·R N Walsh, R A Cummins
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E BlackW T Greenough
Sep 1, 1966·The Journal of Comparative Neurology·M C DiamondE L Bennett
Nov 1, 1969·The Journal of Comparative Neurology·R N WalshR A Cummins
Jan 1, 1981·The International Journal of Neuroscience·R N Walsh
Dec 1, 1994·Journal of Neuroimmunology·M SchroeterG Stoll
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·A L Ohlsson, B B Johansson
Mar 1, 1994·Journal of Neurobiology·A GhoshM E Greenberg
Jun 1, 1996·Behavioural Brain Research·M R Rosenzweig, E L Bennett
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·Z KovácsM Fukui
Nov 15, 1996·Science·A Lumsden, R Krumlauf
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·E Y SnyderJ D Macklis
Oct 31, 1998·Brain Research. Molecular Brain Research·H S OliffC W Cotman
Dec 2, 1998·Reviews in the Neurosciences·M A NicolelisD J Krupa
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Sep 9, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A RisedalB B Johansson
Mar 11, 2000·The European Journal of Neuroscience·C Vicario-AbejónR D McKay
Apr 25, 2000·Cerebrovascular Diseases·G RubinH Yonas
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O AbeY Sasaki
Jun 6, 2000·Trends in Neurosciences·S C Cramer, M Chopp
Jun 28, 2000·The Journal of Comparative Neurology·C S WeickertJ E Kleinman
Sep 7, 2000·The Journal of Comparative Neurology·T D PalmerF H Gage
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·C RamponY Hu
Dec 9, 2000·Physiology & Behavior·B J AndersonJ K Robinson
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D J Anderson

❮ Previous
Next ❯

Citations

May 13, 2011·Neuropsychological Rehabilitation·Giovanni Berlucchi
Mar 25, 2009·Journal of Geriatric Psychiatry and Neurology·Joe VergheseRichard B Lipton
Mar 18, 2008·Journal of Neuroengineering and Rehabilitation·Andrea Zimmermann-SchlatterJohann Steurer
Mar 1, 2008·Future Neurology·Rachel P Allred, Theresa A Jones
Jul 19, 2013·Neural Plasticity·Alessio FaralliDaniela Carulli
Aug 17, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Zeev MeinerRonen R Leker
Nov 7, 2006·Current Opinion in Neurobiology·Randolph J Nudo
Jun 27, 2008·Journal of Clinical Nursing·Jeongok G Logan, Debra J Barksdale
Mar 24, 2009·The European Journal of Neuroscience·Ingegerd SöderströmTommy Olsson
Apr 5, 2013·Development, Growth & Differentiation·Hiromu YawoToru Ishizuka
Sep 4, 2012·British Journal of Neurosurgery·James N ThompsonFayez Morcos
Feb 23, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Yoshio Kaneko, Matcheri Keshavan
Jan 21, 2016·Cell Transplantation·Ji Hea YuSung-Rae Cho
Mar 30, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Barbro B Johansson
Sep 26, 2012·Cell Transplantation·Stephen Polgar
Jan 9, 2008·Current Opinion in Neurology·Steven C Cramer, Jeff D Riley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Stroke; a Journal of Cerebral Circulation
Randolph J Nudo
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jeff BiernaskieDale Corbett
Stroke; a Journal of Cerebral Circulation
Gert KwakkelJos Twisk
© 2022 Meta ULC. All rights reserved