On phagosome individuality and membrane signalling networks

Trends in Cell Biology
Gareth Griffiths

Abstract

Cells such as macrophages take up pathogens into specialized membrane organelles (phagosomes) that fuse with other organelles, including lysosomes, in a process termed maturation. The fully matured phagolysosome is a low-pH, hydrolase-rich killing device that some pathogens can bypass. One might expect that phagosomes containing a given type of particle that entered cells simultaneously via the same receptor would behave the same, at least in a single cell. Surprisingly, however, recent data show that phagosomes formed via the same receptors can find themselves in different chemical states even within the same macrophage. Here, I argue that each phagosome is an individual entity whose behaviour depends on a finite number of stable equilibrium states in its membrane signalling networks.

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