PMID: 10475418Sep 4, 1999

On-pump versus off-pump coronary revascularization: evaluation of renal function

The Annals of Thoracic Surgery
R AscioneG D Angelini

Abstract

Coronary revascularization with cardiopulmonary bypass has the potential risk of renal dysfunction related to the nonphysiologic nature of cardiopulmonary bypass. Recently, there has been a revival of interest in performing myocardial revascularization on the beating heart and we investigated whether this prevents renal compromise. A prospective, randomized, controlled trial was performed in 50 patients (45 males, mean age 61+/-3.7 years) undergoing elective coronary artery bypass grafting. Patients were randomly assigned to conventional revascularization with cardiopulmonary bypass (on pump) or beating heart revascularization (off pump). Glomerular and tubular function were assessed up to 48 hours postoperatively. There were no deaths, myocardial infarctions or acute renal failure in either group. Glomerular filtration as assessed by creatinine clearance and the urinary microalbumin/creatinine ratio was significantly worse in the on pump group (p < 0.0004 and 0.0083, respectively). Renal tubular function was also impaired in the on pump group as assessed by increased N-acetyl glucosaminidase activity (p < 0.0272). These results suggest that off pump coronary revascularization offers a superior renal protection when compared wi...Continue Reading

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Related Concepts

Beta-N-Acetylglucosaminidase
Kidney Function Tests
Creatinine Clearance Measurement
Albumin To Creatinine Protein Ratio Measurement
Kidney Failure, Acute
Renal Glomerular Disease
Revival
Renal Tubule Structure
Myocardium
Myocardial Infarction

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