On reassessment of the chicken TGFB4 gene as TGFB1

Growth Factors
Jaroslava HalperMichael N Romanov

Abstract

Three TGFB isoforms, TGFB1-3, are present in mammalian cells. The presence of four TGFB isoforms has been reported in avian species, though the sequence of TGFB4 was not conclusively determined. Our previously published data show that TGFB4 is actually the chicken ortholog of TGFB1. We mapped TGFB1 but not TGFB4 to linkage group E25C31 on GGA32 next to RYR1 forming a conserved segment with human chromosome HSA19q13.1-q13.2 and, therefore, being definitely the ortholog of human TGFB1. We, therefore, suggest that what was once called chicken "TGFB4" is actually TGFB1. Thus, in the evolutionary lineages of birds and mammals there are only three TGFB isoforms.

Citations

Sep 1, 2009·The Journal of Biological Chemistry·Carlos I Lorda-DiezJuan M Hurle
Oct 31, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Shubash Chandra DasYukinori Yoshimura
Aug 28, 2012·Developmental and Comparative Immunology·Woo H KimWongi Min
Mar 31, 2010·Experimental Eye Research·Ute Mathis, Frank Schaeffel
Oct 30, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·James R CooleyParker B Antin
Sep 6, 2005·Biochemical and Biophysical Research Communications·Dori C WoodsA L Johnson
Jul 2, 2014·Infection and Immunity·Woo H KimWongi Min

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