On serotonin and migraine: a clinical and pharmacological review
Migraine patients have chronically low systemic 5-HT, predisposing them to develop migrainous headache once an attack has been initiated. Changes in platelet 5-HT content are not causally related, but reflect similar changes at a neuronal level. Stimulation of vascular 5-HT1 receptors, probably located in the vessel wall within the dural vascular bed, may alleviate the headache and associated symptoms, but does not interact with earlier mechanisms within the pathophysiological cascade. These receptors are of an as yet unidentified 5-HT1 subtype, closely resembling, but not identical to 5-HT1D receptors. Activation of these receptors results in vasoconstriction, inhibiting depolarization of sensory perivascular afferents within the trigemino-vascular system and thus stopping the headache. Additional inhibition of the release of vasoactive neuropeptides may be involved, but seems to be of only secondary clinical importance.
Antimigraine drug sumatriptan increases blood flow velocity in large cerebral arteries during migraine attacks
Treatment of migraine attacks with sumatriptan. The Subcutaneous Sumatriptan International Study Group
First clinical study of the selective 5-HT3 antagonist, granisetron (BRL 43694), in the acute treatment of migraine headache
Further characterization of the putative 5-HT receptor which mediates blockade of neurogenic plasma extravasation in rat dura mater
Evidence for 5-HT1B/1D receptors mediating the antimigraine effect of sumatriptan and dihydroergotamine
A double-blind comparison of granisetron and placebo for the treatment of acute migraine in the emergency department
Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype
Relationship between serotoninergic measures in blood and cerebrospinal fluid simultaneously obtained in humans
Efficacy of ondansetron (GR 38032F) and the role of serotonin in cisplatin-induced nausea and vomiting
Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells
Efficacy of ICS 205-930, a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, in the prevention of migraine attacks. A complex answer to a simple question. ICS 205-930 Migraine Study Group
Localization of 3H-dihydroergotamine-binding sites in the cat central nervous system: relevance to migraine
Guidelines for controlled trials of drugs in migraine. First edition. International Headache Society Committee on Clinical Trials in Migraine
Contractile 5-HT1 receptors in human isolated pial arterioles: correlation with 5-HT1D binding sites
Cerebral hyperemia during spontaneous cluster headaches with excessive cerebral vasoconstriction to hyperoxia
The antimigraine drug, sumatriptan (GR43175), selectively blocks neurogenic plasma extravasation from blood vessels in dura mater
Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system
Seasonal changes of plasma serotonin and related parameters: correlation with environmental measures
Increased plasma free serotonin but unchanged platelet serotonin in bipolar patients treated chronically with lithium
Characterization of 5-HT receptors mediating contraction of canine and primate basilar artery by use of GR43175, a selective 5-HT1-like receptor agonist
5-HT1-like receptors mediate 5-hydroxytryptamine-induced contraction of human isolated basilar artery
Effect of peripheral benzodiazepine receptor ligands on the contraction of isolated heart atrium and papillary muscle of rats
5-Hydroxytryptamine acts at 5-HT2 receptors to decrease potassium conductance in rat nucleus accumbens neurones
Sensitivity and specificity of transcranial Doppler ultrasonography in the diagnosis of vasospasm following subarachnoid hemorrhage
Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors
The pharmacological properties of the presynaptic serotonin autoreceptor in the pig brain cortex conform to the 5-HT1D receptor subtype
Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?
Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology
Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes
Cluster headache: evidence for a pathophysiologic focus in the superior pericarotid cavernous sinus plexus
The psychopharmacological effects of repeated doses of fluvoxamine, mianserin and placebo in healthy human subjects
Demonstration of monoamine oxidase type B in serotonergic and type A in noradrenergic neurons in the cat dorsal pontine tegmentum by an improved histochemical technique
Serotonin in body fluids: characterization of human plasmatic and cerebrospinal fluid pools by means of a new HPLC method
Neurogenically mediated plasma extravasation in dura mater: effect of ergot alkaloids. A possible mechanism of action in vascular headache
Dihydroergotamine nasal spray in the treatment of attacks of cluster headache. A double-blind trial versus placebo
Focal ischaemia caused by instability of cerebrovascular tone during attacks of hemiplegic migraine. A regional cerebral blood flow study
Effects on migraine headache of MDL 72,222, an antagonist at neuronal 5-HT receptors. Double-blind, placebo-controlled study
Gastric manifestations of autoimmune deficiency syndrome-related Kaposi's sarcoma on computed tomography
5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache
Excretion of free and conjugated 5-HIAA and VMA in urine and concentration of 5-HIAA and HVA in CSF during migraine attacks and free intervals
Total plasma serotonin, 5-hydroxyindoleacetic acid and p-hydroxy-m-methoxymandelic acid excretion in normal and migrainous subjects
Investigation of the venoconstrictor effect of 8' hydroxydihydroergotamine, the main metabolite of dihydroergotamine, in man
Platelet met-enkephalin immunoreactivity and 5-hydroxytryptamine concentrations in migraine patients: effects of 5-hydroxytryptophan, amitriptyline and chlorimipramine treatment
Brainstem influences on the cephalic circulation: experimental data from cat and monkey of relevance to the mechanism of migraine
The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura
A genetic analysis of serotonergic biosynthetic and metabolic enzymes in migraine using a DNA pooling approach
Deficient habituation of evoked cortical potentials in migraine: a link between brain biology, behavior and trigeminovascular activation?
Partial agonism at serotonin 5-HT1B and dopamine D2L receptors using a luciferase reporter gene assay
Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments
Static stabilometry in patients with migraine and tension-type headache during a headache-free period
The relationship between migraine and atopic disorders-the contribution of pulmonary function tests and immunological screening
Endothelial 5-HT receptors mediate relaxation of porcine pulmonary arteries in response to ergotamine and dihydroergotamine
Serotonin 2C receptor gene Cys23Ser polymorphism: a candidate genetic risk factor of migraine with aura in Japanese population
Serotonin depletion can enhance the cerebrovascular responses induced by cortical spreading depression via the nitric oxide pathway
Estrogen-dependent effects of 5-hydroxytryptophan on cortical spreading depression in rat: Modelling the serotonin-ovarian hormone interaction in migraine aura
Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development
The iontophoretic transdermal system formulation of sumatriptan as a new option in the acute treatment of migraine: a perspective
Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4
Psychopathological symptoms in child and adolescent migraine and tension-type headache: a meta-analysis
The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?
Alpha[11C] methyl-L-typtophan positron emission tomography in patients with alternating hemiplegia of childhood
Dopamine and migraine: a review of pharmacological, biochemical, neurophysiological, and therapeutic data
Red wine-induced release of [14C]5-hydroxytryptamine from platelets of migraine patients and controls
Alniditan in the acute treatment of migraine attacks: a subcutaneous dose-finding study. Subcutaneous Alniditan Study Group
Repeatability of the intensity dependence of cortical auditory evoked potentials in the assessment of cortical information processing
Frovatriptan is Effective and Well Tolerated in Korean Migraineurs: A Double-Blind, Randomized, Placebo-Controlled Trial
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer
Early-life treatment of antiserotonin antibodies alters sensitivity to serotonin receptors, nociceptive stimulus and serotonin metabolism in adult rats
Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats
Migraine and cluster headache--their management with sumatriptan: a critical review of the current clinical experience
Increased Brainstem Serotonergic Transporter Availability in Adult Migraineurs: an [(18)F]FP-CIT PET Imaging Pilot Study
The New *G29A and G1222A of HCRTR1 , 5-HTTLPR of SLC6A4 Polymorphisms and Hypocretin-1, Serotonin Concentrations in Migraine Patients
Is the Generally Held View That Intravenous Dihydroergotamine Is Effective in Migraine Based on Wrong "General Consensus" of One Trial? A Critical Review of the Trial and Subsequent Quotations
Relating excitatory and inhibitory neurochemicals to visual perception: A magnetic resonance study of occipital cortex between migraine events
Evaluation of right ventricle functions and serotonin levels during headache attacks in migraine patients with aura
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