On systems and control approaches to therapeutic gain.

BMC Cancer
Tomas RadivoyevitchW David Sedwick

Abstract

Mathematical models of cancer relevant processes are being developed at an increasing rate. Conceptual frameworks are needed to support new treatment designs based on such models. A modern control perspective is used to formulate two therapeutic gain strategies. Two conceptually distinct therapeutic gain strategies are provided. The first is direct in that its goal is to kill cancer cells more so than normal cells, the second is indirect in that its goal is to achieve implicit therapeutic gains by transferring states of cancer cells of non-curable cases to a target state defined by the cancer cells of curable cases. The direct strategy requires models that connect anti-cancer agents to an endpoint that is modulated by the cause of the cancer and that correlates with cell death. It is an abstraction of a strategy for treating mismatch repair (MMR) deficient cancers with iodinated uridine (IUdR); IU-DNA correlates with radiation induced cell killing and MMR modulates the relationship between IUdR and IU-DNA because loss of MMR decreases the removal of IU from the DNA. The second strategy is indirect. It assumes that non-curable patient outcomes will improve if the states of their malignant cells are first transferred toward a sta...Continue Reading

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Citations

Apr 15, 2011·Nucleosides, Nucleotides & Nucleic Acids·T RadivoyevitchS Eriksson
Feb 7, 2012·Nucleosides, Nucleotides & Nucleic Acids·Tomas Radivoyevitch, Charles A Kunos
Jan 18, 2008·Journal of Pharmaceutical Sciences·Ales Prokop, Jeffrey M Davidson
Dec 4, 2012·Cancers·Tomas RadivoyevitchCharles A Kunos

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Software Mentioned

Systems Biology Markup Language ( SBML )
Matlab
MathType
SBMLR
R

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