PMID: 698793Sep 29, 1978Paper

On the appearance of acetylcholine receptors in denervated rat diaphragm, and its dependence on nerve stump length

Brain Research
O Uchitel, N Robbins

Abstract

Acetylcholine (ACh) sensitivity and extrajunctional receptor distribution of the rat diaphragm were closely monitored during the early period following denervation. Both contracture in response to 10 microgram/ml of ACh and extrajunctional binding of [125I]alpha-bungarotoxin ([125I]alpha-BTX)) were first detectable 30 h after cutting the phrenic nerve in the thorax. If the nerve were cut more proximally, leaving a 3.5 cm distal nerve stump, the same level of ACh contracture and [125I]alpha-BTX binding did not appear until 40 h after operation. This 10-h delay was far longer than the 3-h delay in transmission failure reportedly dependent on stump length. The earliest detectable extrajunctional [125I]alpha-BTX binding appeared throughout the entire muscle fiber, and was not localized to the endplate region as would be expected if degeneration in the nerve terminal induced new receptors. However, later significant increases in [125I]alpha-BTX binding at the endplate region could have resulted from such degeneration. All these results are consistent with neurotrophic regulation of muscle ACh receptors, working via a mechanism involving axonal transport.

References

Mar 25, 1976·Nature·A PestronkJ W Griffin
Jan 1, 1976·Cold Spring Harbor Symposia on Quantitative Biology·T Lomo, R H Westgaard
Nov 1, 1975·The Journal of Physiology·T Lomo, R H Westgaard
Mar 15, 1972·Nature: New Biology·J B Harris, S Thesleff
Apr 1, 1970·The Journal of Physiology·R Miledi, C R Slater
Jun 23, 1959·The Journal of Physiology·J AXELSSON, S Thesleff
Apr 1, 1965·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·N EMMELIN, L MALM

Citations

Jan 1, 1979·Journal of Supramolecular Structure·U R Tipnis, S K Malhotra
Jul 21, 1980·Brain Research·B OakleyM A Hosley
Nov 1, 1984·Brain Research·B OakleyS E Hughes
Jan 1, 1983·Progress in Neurobiology·J J McArdle
May 1, 1991·Photochemistry and Photobiology·A A Kyagova Potapenko AYa

Related Concepts

Acetylcholine Sulfate (1: 1)
kappa-Bungarotoxin
Respiratory Diaphragm
Dose-Response Relationship, Drug
Motor Endplate
Inotropism
Muscle Denervation Procedure
Nerve Degeneration
Structure of Phrenic Nerve
Cholinergic Receptors

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