On the atomistic-based continuum viscoelastic constitutive relations for axonal microtubules

Journal of the Mechanical Behavior of Biomedical Materials
Ashfaq AdnanAmit Bagchi

Abstract

Mechanical response of brain's interior during traumatic brain injury is primarily governed by the cytoskeleton (CSK) and occurs over multiple length scales starting from the axonal substructure level. The axonal cytoskeleton can be viewed as a nanofiber reinforced nanocomposite structure where nano-fibrous microtubules (MTs) are arranged in staggered arrays and cross-linked by Tau proteins. Each MT is made of thirteen laterally connected protofilaments (PFs), each of which is formed via linear polymerization of αβ-heterodimer protein called tubulin. Recent studies suggest that the unique viscoelastic nature of axons governs the damage during traumatic brain injury. To understand how the internal substructures of axon influences the viscoelastic mechanical behavior of axon from a theoretical perspective, the viscoelastic properties of MTs need to be properly described. Since viscosity is a bulk property, the measurement methods are fairly consistent. On the other hand, the reported experimentally measured elastic properties of MTs vary by several orders of magnitude due to limitations of experimental tools. Alternatively, many have attempted to determine MT properties using theoretical and computational methods at different len...Continue Reading

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Citations

Mar 3, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Shyam BaduSundeep Singh
Oct 31, 2020·Journal of the Mechanical Behavior of Biomedical Materials·Md Ishak KhanAshfaq Adnan

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