On the Cause and Mechanism of Phenoptosis

Biochemistry. Biokhimii︠a︡
R F Walker

Abstract

Based upon evolvability theory, phenotypes like aging that offer no apparent individual benefit may evolve nonetheless. Pursuant to that concept, the evolution of a hypothetical, genome-based aging program called phenoptosis was proposed. However, while aging may facilitate evolvability, it need not result from a program specifically selected for that purpose. Instead, it is possible that the potential for aging is conserved within the genome as a part of a beneficial program that orchestrates and integrates developmental transformation of the soma from conception to maturation. Because somatic remodeling is inherently unstable, its continued non-programmatic expression beyond young adulthood (developmental inertia) erodes internal order, initiating and exacerbating aging. Thus, aging may result paradoxically from post-maturational expression of the same programmatic function for somatic transformation that previously provided individual benefit. It did so by ensuring acquisition of reproductive competence, post-reproductive development of parents to nurture offspring and thereby, to guarantee species survival. In an attempt to identify genes capable of controlling developmental inertia, we sequenced DNA from a series of subjec...Continue Reading

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Citations

Mar 18, 2019·Biochemistry. Biokhimii︠a︡·G A ShilovskyV P Skulachev
Mar 1, 2018·Biochemistry. Biokhimii︠a︡·M V Skulachev, V P Skulachev
Nov 18, 2020·Biochemistry. Biokhimii︠a︡·B Zhivotovsky

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