On the cause of species differences in digitalis sensitivity

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.

On the cause of species differences in digitalis sensitivity

Abstract

References

Influenceability of cation transport in heart muscle by calcium and strophanthin in relation to inotropic effect

Transmembrane potentials and fluxes in isolated rabbit atria

Isolation of skeletal muscle cell membrane and some of its properties

Some properties of the ATP dependent Na binding system of rat brain microsomes

Effects of ouabain and calcium on potassium balance of isolated guinea pig ventricle

Cation transport and structure of the red-cell plasma membrane

STUDIES ON A NA+ + K+-DEPENDENT, OUABAIN-SENSITIVE ADENOSINE TRIPHOSPHATASE IN THE AVIAN SALT GLAND

ON THE IDENTITY OF THE ION-PUMPING-ATPASE IN THE CELL MEMBRANE OF THE MYOCARDIUM WITH A DIGITALIS RECEPTOR ENZYME

ON THE BIOCHEMICAL MODE OF ACTION OF DIGITALIS

DETOXIFICATION RATE AND ACCUMULATION OF DIGITOXIN IN DIFFERENT SPECIES

STUDIES ON THE CAUSE OF DIGITALIS RESISTANCE IN TOADS

EFFECTS OF CALCIUM ON ISOLATED MAMMALIAN HEART

Citations

A comparison of the effects of ouabain and ethacrynic acid on the dog kidney in vivo and in vitro

Lipophilicity and pharmacodynamics of cardiotonic steroids in guinea-pig isolated heart muscle preparations

Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis).

Pharmacokinetics of digoxin and its 4'''-acetyl- and methylderivates in the rat

Studies on the renal action of ouabain in the rat. Effects in the non-diuretic state

CA2+-free perfusion of rat heart reveals a (Na+ + K+)ATPase form highly sensitive to ouabain

Reinstatement of the ATP high energy paradigm

Two brain inhibitors inhibit renal Na,K-ATPases without recognizing the species-dependent variation of their ouabain-sensitivity

Effects of lithium and thallous ions on sodium pump activity in the guinea-pig heart and their relationship to the positive inotropic action

Correlation of the glycoside response, the force staircase, and the action potential configuration in the neonatal rat heart

Liver cell potentials: in vitro effects of metabolic inhibitors, cardiac glycosides, and hormones

Does digoxin sensitize left ventricular mechanoreceptors?

Proceedings of the British Pharmacological Society. 16--18th December, 1980

Effect of cardiac glycosides and sodium ethacrynate on transepithelial sodium transport in in vivo micropuncture experiments and on isolated plasma membrane Na-K ATPase in vitro of the rat

A comparative study of the action of digoxigenin-mono, bis- and tridigitoxosides in the cat heart-lung preparation (author's transl)

Effect of different bathing media on the short-circuit current across the intestine of the rat and guinea-pig

Dependency of Ca++-adsorption by isolated heart muscle mitochondria upon Na+- and K+-concentration as possible explanation for the inotropic effect of digitalis

Endogenous digitalis-like factors

Action of ouabain on rat heart: comparison with its effect on guinea-pig heart

Cardiac glucosides: correlations among Na+ K+-ATPase, sodium pump and contractility in the guinea pig heart

Factors and agents that influence cardiac glycoside-Na+, K+-ATPase interaction

Myocardial uptake of thallous ion by facilitated diffusion

Involvement of Na+,K(+)-ATPase inhibition in K562 cell differentiation induced by bufalin

Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis

Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes

Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene

Interspecies variation in myocardial physiology: the anomalous rat

Plasma concentration, uptake by liver, and biliary excretion of tritiated cardiac glycosides in the isolated perfused guinea-pig liver

Biochemical basis for the low sensitivity of the rat heart to digitalis

Digitalis. I

Ouabain: temporal relationship between the inotropic effect and the in vitro binding to, and dissociation from, (Na + + K + )- activated ATPase

Short-term effects of calcium, potassium, and of ouabain on metabolite levels in the frog heart in vivo

High-affinity ouabain binding site and low-dose positive inotropic effect in rat myocardium

Active transport of Na + and K + through animal cell membranes

A comparison of the inhibition by cardiac glycosides of the isolated intestine from the rat and the guinea pig

Ouabain-receptor interactions in (Na+ plus K+)-ATPase preparations. IV. The molecular structure of different cardioactive steroids and other substances and their affinity to the glycoside receptor

The lead structure in cardiac glycosides is 5 beta, 14 beta-androstane-3 beta 14-diol

Measurement of cytosolic free calcium concentration in isolated rat ventricular myocytes with quin 2

Effects of psychopharmacological agents on brain metabolism. 3. Effects of imipramine and ouabain on the (Na+ plus K+)activated ATPase from brain microsomes and cooperative interactions with the enzyme

Specific activity and sensitivity of strophanthin of the Na + +K + -activated ATPase in rats and guinea-pigs with hypoadrenalism

Properties of the receptor for cardiac glycosides (author's transl)

5 Beta,14 beta-androstane-3 beta,14-diol binds to the digitalis receptor site on Na/K-ATPase

Inotropic action, myocardial uptake and subcellular distribution of ouabain, digoxin and digitoxin in isolated rat hearts

Digitalis glycosides: a discussion of the similarities and differences in actions and existing controversies

Relationship between inhibition of renal Na+ plus K+-ATPase and natriuresis

Ouabain sensitivity of the Na+, K+-ATPase from rat neonatal and human fetal and adult heart

Site and mechanism of uptake of 3H--norepinephrine by isolated perfused rat lungs

A previously undescribed phenylethanoid glycoside from Callicarpa kwangtungensis Chun acts as an agonist of the Na/K-ATPase signal transduction pathway.

Ouabain-resistant, amiloride-sensitive Na+-K+ pumping activity and morphological changes are inducible.

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