Sep 28, 2015

On the causes of evolutionary transition:transversion bias

BioRxiv : the Preprint Server for Biology
Arlin Stoltzfus, Ryan W. Norris


A pattern in which nucleotide transitions are favored several-fold over transversions is common in molecular evolution. When this pattern occurs among amino acid replacements, explanations often invoke an effect of selection, on the grounds that transitions are more conservative in their effects on proteins. However, the underlying hypothesis of conservative transitions has never been tested directly. Here we assess support for this hypothesis using direct evidence: the fitness effects of mutations in actual proteins, measured via individual or paired growth experiments. We assembled data from 8 published studies, ranging in size from 24 to 757 single-nucleotide mutations that change an amino acid. Every study has the statistical power to reveal significant effects of amino acid exchangeability, and most studies have the power to discern a binary conservative-vs-radical distinction. However, only one study suggests that transitions are significantly more conservative than transversions. In the combined set of 1239 replacements, the chance that a transition is more conservative than a transversion is 53 % (95 % confidence interval, 50 % to 56 %), compared to the null expectation of 50 %. We show that this effect is not large com...Continue Reading

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Mentioned in this Paper

Base Sequence
Single Nucleotide Polymorphism
Amino Acid [EPC]
Transversion Mutation
Evolution, Molecular
Transverse - Anatomical Location
Biological Evolution

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