On the cytoskeleton and soft glassy rheology

Journal of Biomechanics
Kranthi K MandadapuMohammad R K Mofrad

Abstract

The cytoskeleton is a complex structure within the cellular corpus that is responsible for the main structural properties and motilities of cells. A wide range of models have been utilized to understand cytoskeletal rheology and mechanics (see e.g. [Mofrad, M., Kamm, R., 2006. Cytoskeletal Mechanics: Models and Measurements. Cambridge University Press, Cambridge]). From this large collection of proposed models, the soft glassy rheological model (originally developed for inert soft glassy materials) has gained a certain traction in the literature due to the close resemblance of its predictions to certain mechanical data measured on cell cultures [Fabry, B., Maksym, G., Butler, J., Glogauer, M., Navajas, D., Fredberg, J., 2001. Scaling the microrheology of living cells. Physical Review Letters 87, 14102]. We first review classical linear rheological theory in a concise fashion followed by an examination of the soft glassy rheological theory. With this background we discuss the observed behavior of the cytoskeleton and the inherent limitations of classical rheological models for the cytoskeleton. This then leads into a discussion of the advantages and disadvantages presented to us by the soft glassy rheological model. We close wit...Continue Reading

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Citations

Mar 20, 2010·Histochemistry and Cell Biology·Helene M LangevinDouglas J Taatjes
Jun 25, 2009·The European Physical Journal. E, Soft Matter·C Picard, A Donald
Aug 10, 2013·The European Physical Journal. E, Soft Matter·Tomita Vasilica StirbatHélène Delanoë-Ayari
May 9, 2012·Acta Biomaterialia·Antoine Jérusalem, Ming Dao
Apr 19, 2011·Journal of Biomechanics·Brian HoltJeffrey R Morgan
Nov 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kalpana MandalJean-Baptiste Manneville
Mar 1, 2017·Biology of the Cell·Charlotte AlibertJean-Baptiste Manneville
Jul 30, 2020·Molecular Biology of the Cell·Charles W Wolgemuth, Sean X Sun
Jan 31, 2017·Biomechanics and Modeling in Mechanobiology·Horacio López-Menéndez, José Félix Rodríguez
Mar 12, 2021·Biophysical Journal·Moslem Moradi, Ehssan Nazockdast
Apr 1, 2021·Molecular Biology of the Cell·Kirill LavrenyukKris Noel Dahl

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