On the design and efficacy assessment of self-assembling peptide-based hydrogel-glycosaminoglycan mixtures for potential repair of early stage cartilage degeneration

Journal of Peptide Science : an Official Publication of the European Peptide Society
A BarcoR P W Davies

Abstract

Peptide-based hydrogels are of interest for their potential use in regenerative medicine. Combining these hydrogels with materials that may enhance their physical and biological properties, such as glycosaminoglycans, has the potential to extend their range of biomedical applications, for example in the repair of early cartilage degeneration. The aim of this study was to combine three self-assembling peptides (P11 -4, P11 -8, and P11 -12) with chondroitin sulphate at two molar ratios of 1:16 and 1:64 in 130 and 230 mM Na+ salt concentrations. The study investigates the effects of mixing self-assembling peptide and glycosaminoglycan on the physical and mechanical properties at 37°C. Peptide alone, chondroitin sulphate alone, and peptide in combination with chondroitin sulphate were analysed using Fourier transform infrared spectroscopy to determine the β-sheet percentage, transmission electron microscopy to determine the fibril morphology, and rheology to determine the elastic and viscous modulus of the materials. All of the variables (peptide, salt concentration, and chondroitin sulphate molar ratio) had an effect on the mechanical properties, β-sheet formation, and fibril morphology of the hydrogels. P11 -4 and P11 -8-chondroi...Continue Reading

References

Aug 1, 1971·The Journal of Clinical Investigation·H J Mankin, L Lippiello
Oct 1, 1994·British Journal of Rheumatology·J P Urban
Jan 1, 1993·Progress in Biophysics and Molecular Biology·J L ArrondoF M Goñi
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·A AggeliN Boden
Aug 3, 2005·Seminars in Cancer Biology·Shuguang ZhangXiaojun Zhao
Nov 25, 2005·Journal of the American Chemical Society·Matthew S LammDarrin J Pochan
Apr 22, 2006·Journal of Biomedical Materials Research. Part a·Carol J BellJohn Fisher
Apr 25, 2007·Journal of Dental Research·J KirkhamA Aggeli
Aug 10, 2007·Acta Biochimica Et Biophysica Sinica·Jilie Kong, Shaoning Yu
Aug 19, 2007·Biochimica Et Biophysica Acta·Andreas Barth
Jan 10, 2008·PloS One·Aurore SchneiderChristophe Egles
Mar 14, 2008·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J KattaJ Fisher
Apr 3, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shuhei OtsukiMitsuo Kinoshita
Jul 19, 2008·Tissue Engineering. Part a·Kerstin M GallerRena N D'Souza
Aug 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kerstin ElfrinkKlaus Gerwert
Jun 6, 2009·Trends in Biotechnology·Stuart KyleMichael J McPherson
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ramille N ShahSamuel I Stupp
Oct 12, 2010·Biomaterials·Stuart KyleMichael J McPherson
Jul 4, 2012·Biomaterials·Quynhhoa T NguyenRobert L Sah
May 10, 2013·Nanomedicine·Steven MaudeAmalia Aggeli
Feb 6, 2014·Advanced Materials·Job Boekhoven, Samuel I Stupp
May 6, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Youjia ZhuYing Wan
Nov 5, 2014·Annals of Biomedical Engineering·Charles M Rubert PérezSamuel I Stupp
Jul 19, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D E MilesR K Wilcox
Nov 13, 2017·Acta Biomaterialia·A R ArmientoD Eglin

❮ Previous
Next ❯

Citations

May 5, 2021·Advanced Healthcare Materials·James P WarrenPaul A Beales

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.