On the development of a comprehensive MC simulation model for the Gamma Knife Perfexion radiosurgery unit

Physics in Medicine and Biology
E P PappasP Karaiskos

Abstract

This work presents a comprehensive Monte Carlo (MC) simulation model for the Gamma Knife Perfexion (PFX) radiosurgery unit. Model-based dosimetry calculations were benchmarked in terms of relative dose profiles (RDPs) and output factors (OFs), against corresponding EBT2 measurements. To reduce the rather prolonged computational time associated with the comprehensive PFX model MC simulations, two approximations were explored and evaluated on the grounds of dosimetric accuracy. The first consists in directional biasing of the (60)Co photon emission while the second refers to the implementation of simplified source geometric models. The effect of the dose scoring volume dimensions in OF calculations accuracy was also explored. RDP calculations for the comprehensive PFX model were found to be in agreement with corresponding EBT2 measurements. Output factors of 0.819  ±  0.004 and 0.8941  ±  0.0013 were calculated for the 4 mm and 8 mm collimator, respectively, which agree, within uncertainties, with corresponding EBT2 measurements and published experimental data. Volume averaging was found to affect OF results by more than 0.3% for scoring volume radii greater than 0.5 mm and 1.4 mm for the 4 mm and 8 mm collimators, respectively. ...Continue Reading

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Citations

Oct 4, 2019·Physics in Medicine and Biology·Francois Therriault-ProulxA Sam Beddar
Dec 21, 2019·Physics in Medicine and Biology·A LogothetisP Karaiskos
Aug 13, 2021·Physics in Medicine and Biology·Hyojun ParkChul Hee Min
Dec 22, 2021·Medical Physics·Mingli ChenWeiguo Lu

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