Jan 4, 2017

On the developmental self-regulatory dynamics and evolution of individuated multicellular organisms

Journal of Theoretical Biology
Felipe A Veloso

Abstract

Changes in gene expression are thought to regulate the cell differentiation process intrinsically through complex epigenetic mechanisms. In fundamental terms, however, this assumed regulation refers only to the intricate propagation of changes in gene expression or else leads to non-explanatory regresses. The developmental self-regulatory dynamics and evolution of individuated multicellular organisms also lack a unified and falsifiable description. To fill this gap, I computationally analyzed publicly available high-throughput data of histone H3 post-translational modifications and mRNA abundance for different Homo sapiens, Mus musculus, and Drosophila melanogaster cell-type/developmental-period samples. My analysis of genomic regions adjacent to transcription start sites generated a profile from pairwise partial correlations between histone modifications controlling for the respective mRNA levels for each cell-type/developmental-period dataset. I found that these profiles, while explicitly uncorrelated with the respective transcriptional "identities" by construction, associate strongly with cell differentiation states. This association is not expected if cell differentiation is, in effect, regulated by epigenetic mechanisms. B...Continue Reading

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Mentioned in this Paper

Genome
Post-Translational Protein Processing
Regulation of Biological Process
Transcription Initiation Site
Transcription, Genetic
Regulation of Intrinsic Apoptosis
Extracellular Space
Genome Assembly Sequence
House mice
Gene Expression

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