On the dynamics of the adenylate energy system: homeorhesis vs homeostasis

PloS One
Ildefonso M De la FuenteLuis Martínez


Biochemical energy is the fundamental element that maintains both the adequate turnover of the biomolecular structures and the functional metabolic viability of unicellular organisms. The levels of ATP, ADP and AMP reflect roughly the energetic status of the cell, and a precise ratio relating them was proposed by Atkinson as the adenylate energy charge (AEC). Under growth-phase conditions, cells maintain the AEC within narrow physiological values, despite extremely large fluctuations in the adenine nucleotides concentration. Intensive experimental studies have shown that these AEC values are preserved in a wide variety of organisms, both eukaryotes and prokaryotes. Here, to understand some of the functional elements involved in the cellular energy status, we present a computational model conformed by some key essential parts of the adenylate energy system. Specifically, we have considered (I) the main synthesis process of ATP from ADP, (II) the main catalyzed phosphotransfer reaction for interconversion of ATP, ADP and AMP, (III) the enzymatic hydrolysis of ATP yielding ADP, and (IV) the enzymatic hydrolysis of ATP providing AMP. This leads to a dynamic metabolic model (with the form of a delayed differential system) in which t...Continue Reading


Mar 11, 1975·Journal of Bacteriology·W J Ball, D E Atkinson
Jan 14, 1968·Journal of Molecular Biology·D BlangyJ Monod
Mar 1, 1968·European Journal of Biochemistry·E E Sel'kov
Oct 1, 1972·Biophysical Journal·Albert Goldbeter, R Lefever
Dec 1, 1971·Journal of Bacteriology·A G ChapmanD E Atkinson
Dec 18, 1972·Biochemical and Biophysical Research Communications·R F Derr, L Zieve
Mar 23, 1974·FEBS Letters·J G Reich, E E Sel'kov
Apr 7, 1972·Biochimica Et Biophysica Acta·E ThumaI Schirmer
May 11, 1968·Nature·C H Waddington
Jun 7, 1969·Nature·D C Mills, D P Thomas
Jan 1, 1980·Annual Review of Biochemistry·J R Knowles
Jun 1, 1980·Journal of Bacteriology·B A Smith, M Dworkin
Jun 1, 1981·Journal of Bacteriology·K D Beaman, J D Pollack
Sep 1, 1994·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J M FuentesJ A Madrid
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·O ShaulD Inze
Apr 15, 1996·Archives of Biochemistry and Biophysics·N ErcanFrank Q Nuttall
Jan 1, 1996·Bio Systems·Ildefonso M De la FuenteJuan Veguillas
Nov 1, 1996·Biophysical Journal·I Martinez de la FuenteJ M Aguirregabiria
Apr 29, 1998·Acta Biotheoretica·Ildefonso M De la FuenteJuan Veguillas
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·T TakagiS Buratowski
Apr 16, 1999·Nature Neuroscience·C VirginioA Surprenant
Jun 15, 1999·Bio Systems·Ildefonso M De la Fuente
Jul 31, 1999·The Journal of Biological Chemistry·X R ShengX M Pan
Nov 7, 1999·Progress in Brain Research·G Burnstock
Dec 2, 1999·Nature·S DanøF Hynne
Jun 22, 2000·Biochemical and Biophysical Research Communications·S Nath, S Jain
Aug 10, 2000·The Journal of Clinical Investigation·L GettyR N Bergman
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P RajabP L Greenhaff
Oct 18, 2000·Nature·H JeongA L Barabási
Feb 17, 2001·Current Opinion in Structural Biology·R J Ellis
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·H R Petty, A L Kindzelskii
Mar 21, 2001·Nature Reviews. Neuroscience·B S Khakh
Apr 9, 2001·Science·H Zhu, H F Bunn
Jul 4, 2001·The Journal of Physiology·D Placantonakis, J Welsh
Jan 30, 2002·Diabetes·Robert T KennedySung-Kwon Jung
Feb 21, 2002·The Journal of Biological Chemistry·Scott W NelsonHerbert J Fromm
Mar 6, 2002·Physiological Measurement·A EkeL R Kozak
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Giovanni ManfrediMarina Mattiazzi
Jun 18, 2002·American Journal of Physiology. Endocrinology and Metabolism·Nacide Ercan-FangFrank Q Nuttall
Aug 31, 2002·Science·E RavaszA L Barabási
Sep 25, 2002·Physiological Reviews·R Alan North
Dec 10, 2002·Science·G ManningS Sudarsanam
Feb 8, 2003·Journal of Neurophysiology·Mahasweta DasCraig D Lewis
Feb 14, 2003·Biotechnology and Bioengineering·Michael HansChristoph Wittmann
Mar 15, 2003·Bioscience Reports·Fazoil I Ataullakhanov, Victor M Vitvitsky
Oct 3, 2003·The Journal of Biological Chemistry·Michael J MacDonaldMindy A Kendrick
Dec 17, 2003·Current Opinion in Structural Biology·Wim Versées, Jan Steyaert
Jan 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sebastian MarquezMario E Guido
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Robert R KleveczDouglas B Murray
Nov 30, 2004·Animal Genetics·T BønsdorffI Olsaker
Mar 9, 2005·The FEBS Journal·Matthieu JulesJean Luc Parrou
Jun 7, 2005·Trends in Biochemical Sciences·David Lloyd, Douglas B Murray
Jun 21, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T JacobA Hingorani
Jun 22, 2005·PLoS Biology·Anna OlivaJanet Leatherwood
Sep 2, 2005·American Journal of Physiology. Cell Physiology·Sergio Sánchez-ArmássRaul Martínez-Zaguilán
Sep 30, 2005·BMC Genomics·Bing TianAllan R Brasier
Oct 4, 2005·The European Journal of Neuroscience·Magdalena Sanhueza, Juan Bacigalupo
Feb 2, 2006·Annals of Biomedical Engineering·Ildefonso M De la FuenteA Vera-Lopez
Mar 21, 2006·FEBS Letters·David Lloyd, Douglas B Murray
Mar 28, 2006·Biophysical Journal·V Krishnan RamanujanBrian A Herman
May 30, 2006·Biochimica Et Biophysica Acta·Joachim Weber
Aug 4, 2006·The FEBS Journal·Edelmira ValeroFrancisco García-Carmona
Oct 4, 2006·Biophysical Chemistry·J SrividhyaSantiago Schnell
Oct 13, 2006·Biophysical Chemistry·A C MøllerLars Folke Olsen
Oct 14, 2006·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Adrian D HaimovichWilliam J Welsh
Nov 24, 2006·Eukaryotic Cell·A Katrin HungerbuehlerAmy S Gladfelter
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Douglas B MurrayHiroaki Kitano
Jun 16, 2007·Current Biology : CB·Cecilia Garmendia-TorresMichel Jacquet
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·K-H Chiam, Gunaretnam Rajagopal
Sep 7, 2007·Trends in Microbiology·Shannon R Mackey, Susan S Golden
Sep 22, 2007·Bulletin of Mathematical Biology·Ildefonso M De la FuenteJuan Veguillas
Oct 30, 2007·Journal of Bacteriology·Michael H BucksteinHarvey Rubin
Dec 22, 2007·Nature·Jeffrey R ChabotAlexander van Oudenaarden
Dec 29, 2007·Plant Physiology·Peter Robert LangeRita Zrenner
Jan 29, 2008·Toxicon : Official Journal of the International Society on Toxinology·Ruihua DaiYining Hou
Feb 12, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Wimmerstedt, G Kahlmeter
Mar 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stefan SteigmillerPeter Gräber
May 3, 2008·Luminescence : the Journal of Biological and Chemical Luminescence·Malalanirina Sylvia Rakotonirainy, Sylvia Arnold
Sep 5, 2008·PloS One·Ildefonso M De la FuenteAntonio Vera-López
Oct 25, 2008·The Journal of Biological Chemistry·Jun-Hai YangJames N Weiss
Nov 5, 2008·PloS One·Miguel A AonDavid Lloyd
Feb 10, 2009·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·I S ZybatkinaM V Savina
Aug 29, 2009·The European Journal of Neuroscience·Alisa D WomacMark J Zoran
Nov 6, 2009·PloS One·Ildefonso M De la FuenteJuan Veguillas
Dec 3, 2009·Molecular Systems Biology·Harish ShankaranH Steven Wiley
Mar 9, 2010·PloS One·Ildefonso M De la FuenteAntonio Vera-López
Jun 29, 2010·Journal of Bacteriology·Anja NenningerConrad W Mullineaux
Sep 8, 2010·Trends in Cell Biology·Kiwamu TanakaGary Stacey
Oct 1, 2010·The Journal of Biological Chemistry·Veli Cengiz ÖzalpLars Folke Olsen
Oct 20, 2010·International Journal of Molecular Sciences·Ildefonso M De la Fuente
Oct 22, 2010·Nature·Nick Lane, William Martin
Jan 22, 2011·Journal of Asian Natural Products Research·Wen-Jun DuanTakashi Ikejima
Jan 29, 2011·Nature·John S O'Neill, Akhilesh B Reddy
Apr 5, 2011·Environmental Microbiology Reports·Johannes HolertHeribert Cypionka
Apr 15, 2011·Nature·D Grahame Hardie
May 25, 2011·The FEBS Journal·Naoki SogaToshiharu Suzuki
Jun 8, 2011·PloS One·Assaf GottliebDavid Horn
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeff F BurkeenMark J Zoran
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alison M ForsythHoward A Stone
Aug 2, 2011·Biochimica Et Biophysica Acta·Léonie G M BoenderPascale Daran-Lapujade
Dec 3, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Cecilie K YttingLars Folke Olsen
Jan 5, 2012·PloS One·Thomas BollingerWerner Solbach
Mar 3, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dhaval P BhattThad A Rosenberger
Mar 7, 2012·PloS One·Ildefonso M De la Fuente, Jesus M Cortes
Mar 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Catheline PlaideauMark H Rider
Sep 4, 2012·Scientific Reports·Myong-Hee Sung, Gordon L Hager
Jan 24, 2013·Biochemistry·Jörgen ÅdénMagnus Wolf-Watz
Apr 5, 2013·PloS One·Ildefonso M De la FuenteJuan Veguillas
Jun 8, 2013·Journal of Neuroscience Methods·K T Blackwell
Jul 16, 2013·Interface Focus·Simonetta FalzoniFrancesco Di Virgilio
Sep 10, 2013·International Journal of Data Mining and Bioinformatics·Jan Geryk, Frantisek Slanina
Jun 8, 2015·Autonomic Neuroscience : Basic & Clinical·Brian F King
Sep 22, 2015·Nature Neuroscience·Mufeng LiKenton J Swartz


Jan 23, 2016·BMC Systems Biology·Edelmira ValeroFrancisco García-Carmona
Feb 1, 2015·Ecotoxicology and Environmental Safety·Renata J Menéndez-HelmanAlfredo Salibián
Mar 1, 2018·The Journal of Biological Chemistry·J Scott LeeSean P Colgan
Aug 18, 2017·The Journal of Endocrinology·Andrea StojakovicKabirullah Lutfy
Jun 4, 2019·Birth Defects Research·Nils J Bergman
Jan 26, 2020·Applied and Environmental Microbiology·Silvia J Salgar-ChaparroLaura L Machuca
Dec 21, 2019·Journal of Experimental Botany·Sandra Díaz-TroyaFrancisco J Florencio
Aug 22, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gustavo N CecchinoJuan A García-Velasco
Aug 25, 2020·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Henry V JakubowskiCassidy R Terrell
May 31, 2020·Microbial Cell Factories·Eleni VasilakouS Aljoscha Wahl

Related Concepts

Magnesium ADP
Adenosine Triphosphate, Chromium Ammonium Salt
In Silico
Energy Metabolism
Adenine Nucleotides
Adenosine Diphosphate
Adenosine Triphosphate
Base Sequence

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
C SugunaS Sinha
International Journal of Molecular Sciences
Ildefonso M De la Fuente
© 2021 Meta ULC. All rights reserved