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On the entropy of protein folding

Protein Science : a Publication of the Protein Society

Mar 1, 1996

George I Makhatadze, Peter L Privalov

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Abstract

The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.

Mentioned in this Paper

Protein Folding
Thermodynamics
Bacillus amyloliquefaciens ribonuclease
Protein Folding, Globular
Staphylococcal Protein A
Ubiquitins
Calorimetry
Protein Unfolding
Alkaline Ribonuclease
1
135
Paper Details
References
  • References45
  • Citations16
  • References45
  • Citations16
12

On the entropy of protein folding

Protein Science : a Publication of the Protein Society

Mar 1, 1996

George I Makhatadze, Peter L Privalov

PMID: 8868487

DOI: 10.1002/pro.5560050312

Abstract

The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.

Mentioned in this Paper

Protein Folding
Thermodynamics
Bacillus amyloliquefaciens ribonuclease
Protein Folding, Globular
Staphylococcal Protein A
1
135

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Paper Details
References
  • References45
  • Citations16
  • References45
  • Citations16
12

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