Abstract
For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be estimated and can be utilized to parameterize the variance of a polygenic effect for population-based samples. Therefore narrow sense heritability, which is both population and trait specific, can be estimated with both population- and family-based samples. In this study we estimate heritability from both family-based and population-based samples, collected in Korea, and the heritability estimates from the pooled samples were, for height, 0.60; body mass index (BMI), 0.32; log-transformed triglycerides (log TG), 0.24; total cholesterol (TCHL), 0.30; high-density lipoprotein (HDL), 0.38; low-density lipoprotein (LDL), 0.29; systolic blood pressure (SBP), 0.23; and diastolic blood pressure (DBP), 0.24. Furthermore, we found differences in how heritability is estimated--in particular the amount of variance attributable to common environment in twins can be substantial--which indicates heritability estimates should be interpreted with c...Continue Reading
References
Jan 1, 1992·Human Heredity·R C ElstonF Severtson
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Mar 10, 2001·Science·L Peltonen, V A McKusick
Jul 26, 2002·Briefings in Bioinformatics·Frühling V Rijsdijk, Pak C Sham
Dec 21, 2004·Human Genomics·Robert C Elston, Courtney Gray-McGuire
Jul 25, 2006·Nature Genetics·Alkes L PriceDavid Reich
Aug 29, 2006·PLoS Genetics·Giuseppe PiliaDavid Schlessinger
Jan 27, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Joohon SungYun-Mi Song
Mar 6, 2008·Nature Reviews. Genetics·Peter M VisscherNaomi R Wray
Apr 28, 2009·Nature Genetics·Yoon Shin ChoHyung-Lae Kim
Jun 22, 2010·Nature Genetics·Jian YangPeter M Visscher
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
May 10, 2011·Nature Genetics·Jian YangPeter M Visscher
Jan 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Or ZukEric S Lander
Jul 4, 2012·American Journal of Human Genetics·Timothy ThorntonNeil Risch
Dec 12, 2012·American Journal of Human Genetics·Doug SpeedDavid J Balding
Aug 7, 2013·Journal of Lipid Research·Jenny van DongenDorret I Boomsma
Aug 21, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Melanie NeijtsEco J C de Geus