On the evolution of hexose transporters in kinetoplastid Protozoans [corrected].

PloS One
Claudio A Pereira, Ariel Mariano Silber

Abstract

Glucose, an almost universally used energy and carbon source, is processed through several well-known metabolic pathways, primarily glycolysis. Glucose uptake is considered to be the first step in glycolysis. In kinetoplastids, a protozoan group that includes relevant human pathogens, the importance of glucose uptake in different phases of the life cycles is well established, and hexose transporters have been proposed as targets for therapeutic drugs. However, little is known about the evolutionary history of these hexose transporters. Hexose transporters contain an intracellular N- and C- termini, and 12 transmembrane spans connected by alternate intracellular and extracellular loops. In the present work we tested the hypothesis that the evolutionary rate of the transmembrane span is different from that of the whole sequence and that it is possible to define evolutionary units inside the sequence. The phylogeny of whole molecules was compared to that of their transmembrane spans and the loops connecting the transmembrane spans. We show that the evolutionary units in these proteins primarily consist of clustered rather than individual transmembrane spans. These analyses demonstrate that there are evolutionary constraints on the...Continue Reading

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Citations

May 9, 2014·Frontiers in Plant Science·Paul DeanT Martin Embley

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Software Mentioned

TriTryp
Multiple Em for Motif Elicitation ( MEME )
TMHMM
BIONJ
ClustalW
Molecular Evolutionary Genetics Analysis ( MEGA )
BLASTp
Vector NTI
SOSUI

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