On the existence of a central respiratory oxygen sensor.

Journal of Applied Physiology
Alexander V Gourine, Gregory D Funk

Abstract

A commonly held view that dominates both the scientific and educational literature is that in terrestrial mammals the central nervous system lacks a physiological hypoxia sensor capable of triggering increases in lung ventilation in response to decreases in Po2 of the brain parenchyma. Indeed, a normocapnic hypoxic ventilatory response has never been observed in humans following bilateral resection of the carotid bodies. In contrast, almost complete or partial recovery of the hypoxic ventilatory response after denervation/removal of the peripheral respiratory oxygen chemoreceptors has been demonstrated in many experimental animals when assessed in an awake state. In this essay we review the experimental evidence obtained using in vitro and in vivo animal models, results of human studies, and discuss potential mechanisms underlying the effects of CNS hypoxia on breathing. We consider experimental limitations and discuss potential reasons why the recovery of the hypoxic ventilatory response has not been observed in humans. We review recent experimental evidence suggesting that the lower brain stem contains functional oxygen sensitive elements capable of stimulating respiratory activity independently of peripheral chemoreceptor in...Continue Reading

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Citations

Dec 24, 2017·Glia·Nephtali MarinaAlexander V Gourine
Jun 14, 2018·Physiology·Bruce G LindseyKendall F Morris
Jun 28, 2018·The Journal of Physiology·Gregory D Funk, Alexander V Gourine
Jun 28, 2018·The Journal of Physiology·Gregory D Funk, Alexander V Gourine
May 10, 2018·The Journal of Physiology·Jan Marino RamirezIbis M Agosto-Marlin
Jan 27, 2018·Nature Communications·Shahriar SheikhbahaeiAlexander V Gourine
Jan 18, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Gary C MouradianMatthew R Hodges
Feb 2, 2019·The Journal of Physiology·Catherine M CzeislerJosé J Otero
Jan 4, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Madeleine M PuissantMatthew R Hodges
Dec 12, 2019·The Journal of Physiology·James DuffinJoseph A Fisher
Oct 17, 2019·Annual Review of Physiology·Patricia Ortega-Sáenz, José López-Barneo
May 21, 2020·International Journal of Molecular Sciences·A Mark Evans, D Grahame Hardie
Sep 28, 2018·Nature·Andy J ChangMark A Krasnow
Oct 14, 2017·Journal of Applied Physiology·Robert C RoachPeter H Hackett
Aug 28, 2020·Brain Sciences·Patrick S HosfordShahriar SheikhBahaei
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Sep 25, 2021·Physiological Reports·Alexia MontalantJean-François Perrier
Oct 26, 2021·Frontiers in Physiology·Isato FukushiYasumasa Okada

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Methods Mentioned

BETA
bilateral resection
transgenic
biosensor

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