PMID: 1178061Jan 1, 1975

On the formation of adrenergic amine storage granules as measured by reserpine labeling

Naunyn-Schmiedeberg's Archives of Pharmacology
A Giachetti, P A Shore

Abstract

Reserpine appears to be bound specifically and irreversibly to amine storage granules in the adrenergic neuron. The presence of reserpine persistently attached to amine granule should reflect the life span of the vesicles, and any additional binding of reserpine should then measure the rate of appearance of newly formed amine granules. Measurement of the persistent binding of tritiated reserpine (3H-Reserpine) in hearts of rats given labeled compound at various times after a saturating dose of unlabeled reserpine showed that the recovery of 3H-reserpine binding capacity occurred rapidly. Four days after reserpine the 3H-reserpine binding was 30% of control rats. The rate of return of binding capacity was then slowed being 65% of normal in 24 days. Calculation of the mean daily increment of binding capacity showed that the rate was an inverse linear function of the binding capacitu existing in the neurone at an early phase (1--8 days) but became constant at a later interval (8--24 days). It is suggested that the return of reserpine binding capacity reflects the appearance of new storage granules and that the rate of storage granule synthesis in the cell body is under feedback control. The signal for enhanced granule formation do...Continue Reading

References

Jul 1, 1972·The Journal of Pharmacy and Pharmacology·J Häggendal, A Dahlström
Sep 1, 1974·The Journal of Physiology·A G GarciaA R Wakade
Jul 3, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·A GiachettiP A Shore
Jan 1, 1968·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·H Thoenen, J P Tranzer
Oct 1, 1969·The Journal of Pharmacy and Pharmacology·A Dahlström, J Häggendal
Feb 1, 1971·The Journal of Pharmacy and Pharmacology·J Häggendal, A Dahlström
Jun 1, 1969·Biochemical Pharmacology·H S Alpers, P A Shore
Jul 1, 1966·Acta Physiologica Scandinavica·A Dahlström, J Häggendal

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