On the formation of discoidal versus threadlike micelles in dilute aqueous surfactant/lipid systems

Langmuir : the ACS Journal of Surfaces and Colloids
Emma JohanssonKatarina Edwards

Abstract

In a recent study, we showed that the surfactant 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-N-[methoxy(polyethylene glycol)-2000 (DSPE-PEG2000) induced mixed micelles of either threadlike or discoidal shape when mixed with different types of lipids. In this study, we have exchanged the PEG-lipid for the more conventional surfactants octaethylene glycol monododecyl ether (C12E8), hexadecyltrimethylammonium bromide (CTAB), and sodium dodecyl sulfate (SDS). Cryo-TEM investigations show that also these surfactants are able to induce the formation of long-lived discoidal micelles. Generally, the preference for either discoidal or threadlike micelles can be tuned by the choice of lipids and environmental conditions in much the same way as observed for the lipid/PEG-lipid system. Our investigation showed, furthermore, that the choice of surfactant may influence the type of mixed micelles formed. It is argued that the formation of discoidal rather than threadlike micelles may be rationalized as an effect of increasing bending rigidity. Our detailed theoretical model calculations show that the bending rigidity becomes significantly raised for aggregates formed by an ionic rather than a nonionic surfactant.

References

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Citations

Dec 29, 2013·Journal of Colloid and Interface Science·Svetoslav E AnachkovKavssery P Ananthapadmanabhan
Apr 10, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Raquel F CorreiaSuzana M Andrade
Nov 7, 2009·Journal of Pharmaceutical Sciences·Per WessmanDenny Mahlin
Mar 8, 2013·Progress in Nuclear Magnetic Resonance Spectroscopy·Ulrich H N DürrAyyalusamy Ramamoorthy
Sep 10, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Malin M ZetterbergKatarina Edwards
Aug 13, 2010·Journal of Colloid and Interface Science·Maria Isabel ViseuAnabela C Fernandes
Dec 23, 2008·Chemistry and Physics of Lipids·Doaa AwadDetlef Gabel
Mar 11, 2016·Chemistry : a European Journal·Sumit KumarChristoph Böttcher
May 23, 2012·Journal of Colloid and Interface Science·Raquel F CorreiaJosé M G Martinho
Sep 7, 2016·Journal of Colloid and Interface Science·Malin Morin ZetterbergKatarina Edwards
Feb 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N DepaloM L Curri
Jun 7, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Ramsey N MajzoubCyrus R Safinya
Feb 1, 2013·The Journal of Physical Chemistry. B·Ming Tang, W Craig Carter

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