On the functional relevance of frontal cortex for passive and voluntarily controlled bistable vision

Cerebral Cortex
T A de GraafA T Sack


In bistable vision, one constant ambiguous stimulus leads to 2 alternating conscious percepts. This perceptual switching occurs spontaneously but can also be influenced through voluntary control. Neuroimaging studies have reported that frontal regions are activated during spontaneous perceptual switches, leading some researchers to suggest that frontal regions causally induce perceptual switches. But the opposite also seems possible: frontal activations may themselves be caused by spontaneous switches. Classically implicated in attentional processes, these same regions are also candidates for the origins of voluntary control over bistable vision. Here too, it remains unknown whether frontal cortex is actually functionally relevant. It is even possible that spontaneous perceptual switches and voluntarily induced switches are mediated by the same top-down mechanisms. To directly address these issues, we here induced "virtual lesions," with transcranial magnetic stimulation, in frontal, parietal, and 2 lower level visual cortices using an established ambiguous structure-from-motion stimulus. We found that dorsolateral prefrontal cortex was causally relevant for voluntary control over perceptual switches. In contrast, we failed to ...Continue Reading


Dec 1, 1985·Perceptual and Motor Skills·R M Liebert, B Burk
Jan 1, 1982·Perception·A BorsellinoA Trabucco
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Corbetta
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·G TononiG M Edelman
Jun 25, 1998·Science·E D LumerGeraint Rees
Jan 28, 1999·Proceedings. Biological Sciences·Andreas KleinschmidtR S Frackowiak
Feb 11, 1999·Journal of Adolescence
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·E D Lumer, Geraint Rees
Jun 23, 1999·Trends in Cognitive Sciences·D A Leopold, Nikos K Logothetis
Dec 5, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·D StrüberM Stadler
Mar 22, 2002·NeuroImage·Philipp SterzerAndreas Kleinschmidt
Apr 23, 2002·Nature Reviews. Neuroscience·Geraint ReesChristof Koch
Apr 8, 2003·Journal of Vision·Sang-Hun Lee, Randolph Blake
Apr 1, 1953·Journal of Experimental Psychology·H WALLACH, D N O'CONNELL
Dec 16, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Chris ChristodoulouTrevor G Clarkson
Jan 9, 2004·Perception & Psychophysics·Thomas C Toppino
Dec 2, 2004·Vision Research·Raymond van EeG J Brouwer
Dec 8, 2004·Nature Neuroscience·Sang-Hun LeeDavid J Heeger
Jun 1, 2005·Brain Research. Cognitive Brain Research·Scott D Slotnick, Steven Yantis
Jun 1, 2005·Vision Research·K MoutoussisNikos K Logothetis
Jun 14, 2005·Consciousness and Cognition·Hamid Reza Naghavi, Lars Nyberg
Jul 12, 2005·Trends in Cognitive Sciences·Chai-Youn Kim, Randolph Blake
Aug 24, 2005·Nature Neuroscience·Ming MengFrank Tong
Oct 20, 2005·Nature Neuroscience·Klaus WunderlichSabine Kastner
Mar 4, 2006·Journal of Cognitive Neuroscience·Sabine WindmannOnur Güntürkün
Sep 21, 2006·Psychological Science·Chris L E PaffenFrans A J Verstraten
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·G J Brouwer, Raymond van Ee
May 26, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark G StokesJason B Mattingley
Sep 1, 2007·Neuroreport·Felix SchothHelmut Buchner
Nov 17, 2007·Journal of Cognitive Neuroscience·Philipp Sterzer, Geraint Rees
Dec 25, 2007·Brain and Cognition·Michael A PittsJanice L Nerger
Aug 7, 2008·Brain and Cognition·Jürgen KornmeierMichael Bach
Jan 6, 2009·Central Nervous System Agents in Medicinal Chemistry·Dimitrios Kapogiannis, Eric M Wassermann
Jan 17, 2009·Journal of Vision·Vani Pariyadath, David M Eagleman
Jun 23, 2009·Trends in Cognitive Sciences·Philipp SterzerGeraint Rees
Oct 7, 2009·Journal of Cognitive Neuroscience·T A de GraafA T Sack
Oct 17, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Simone RossiSafety of TMS Consensus Group
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan W BrascampRaymond van Ee
Mar 27, 2010·Vision Research·David AlaisRaymond van Ee
Jul 6, 2010·Attention, Perception & Psychophysics·Chris L E Paffen, Stefan Van der Stigchel
Aug 24, 2010·Current Biology : CB·Ryota KanaiGeraint Rees
Sep 28, 2010·Current Biology : CB·David CarmelGeraint Rees
Sep 28, 2010·Current Biology : CB·Colin W G Clifford
Oct 20, 2010·Neuroscience and Biobehavioral Reviews·T A de Graaf, A T Sack
Nov 26, 2010·Current Biology : CB·Natalia ZaretskayaAndreas Bartels


Nov 28, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Phillip C F LawTrung T Ngo
Aug 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Megan WangBiyu J He
Mar 1, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas KleinschmidtGeraint Rees
Jul 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tomas KnapenRandolph Blake
Nov 21, 2015·Trends in Cognitive Sciences·Naotsugu TsuchiyaVictor A F Lamme
Aug 30, 2011·Journal of Neuroscience Methods·Alice VarnavaChristopher D Chambers
Dec 3, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Marine VernetAlvaro Pascual-Leone
Dec 24, 2011·Neuroscience and Biobehavioral Reviews·Jaan AruLucia Melloni
Jun 10, 2011·Neuroscience and Biobehavioral Reviews·T A de GraafA T Sack
Feb 3, 2015·Neuropsychologia·Mirella Díaz-SantosAlice Cronin-Golomb
Oct 9, 2014·Frontiers in Psychology·T A de Graaf, Alexander T Sack
Apr 27, 2016·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Mirella Díaz-SantosAlice Cronin-Golomb
Jun 30, 2017·Human Brain Mapping·João Valente DuarteMiguel Castelo-Branco
Jan 1, 2012·Brain Sciences·Christianne Jacobs, A T Sack
Mar 15, 2015·Journal of the International Neuropsychological Society : JINS·Mirella Díaz-SantosAlice Cronin-Golomb
Aug 31, 2017·Annual Review of Psychology·Jan W BrascampTomas Knapen
Jun 4, 2019·Journal of Vision·Alexander PastukhovClaus-Christian Carbon
May 29, 2018·Nature Communications·Hagar Gelbard-SagivItzhak Fried
Aug 6, 2020·NPJ Schizophrenia·Ariel Swyer, Albert R Powers
Sep 29, 2017·Frontiers in Psychology·Xiaogang WangJiang Qiu
May 10, 2018·Scientific Reports·Susan L DenhamIstván Winkler

Related Concepts

Structure of Broca's Area
Motion Perception
Parietal Lobe
Photic Stimulation
Visual Cortex
Transcranial Magnetic Stimulation, Single Pulse
Cerebral Cortex
Down Syndrome

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
E D Lumer, Geraint Rees
Proceedings of the National Academy of Sciences of the United States of America
Philipp Sterzer, Andreas Kleinschmidt
© 2021 Meta ULC. All rights reserved