PMID: 6168724Sep 1, 1981Paper

On the heterogeneity of murine natural killer cells

The Journal of Experimental Medicine
N MinatoB R Bloom

Abstract

The heterogeneity of cells capable exerting spontaneous cytotoxicity in vitro was explored using antisera to several genetically determined surface markers on mouse lymphocytes. Four phenotypes of cells derived either from fresh or cultured murine lymphoid tissue were found to exert natural killer (NK) activity in vitro. One affector cell subset, termed NKI cells, had the serological phenotype of Thy-1-, Lyt-2-, Qa5+, and lysed measles virus persistently infected target cells (HeLa-Ms) but not P815 mastocytoma cells. It corresponds with the NK cells described in most systems in which lymphoma targets are commonly used. A second subset, with the same target cell specificity, termed NKT is a thymus-independent cell with the phenotype Thy-1+, Lyt-2-, Qa-5+, Ly-5+. A third subset of NK cells, termed T killer (TK) cells deriving from cultures of conventional but not nude mouse spleens, mediated spontaneous cytotoxicity of P815 mastocytoma cells, but not of virus-infected targets. It has a phenotype of Thy-1+, Lyt-2+, Qa-5-, Ly-5+, apparently identical with that of conventional, antigen-specific cytotoxic T lymphocytes. The fourth phenotype of NK cells, termed NKM, derived primarily from cultures of bone marrow, is cytotoxic for HeLa...Continue Reading

References

Jun 1, 1979·The Journal of Experimental Medicine·S GillisK A Smith
Jan 1, 1977·The Journal of Experimental Medicine·L GlimcherH Cantor
May 1, 1979·The Journal of Experimental Medicine·N MinatoL M Reid
Sep 19, 1979·The Journal of Experimental Medicine·M ChunM K Hoffmann
Oct 21, 1976·Nature·C ShustikS D Waksal
Sep 15, 1972·Nature·I GresserD Brouty-Boyé
Jul 1, 1980·The Journal of Experimental Medicine·N MinatoB R Bloom
Sep 1, 1980·The Journal of Experimental Medicine·T Hünig, M J Bevan
Mar 1, 1981·The Journal of Experimental Medicine·M Ullberg, M Jondal

❮ Previous
Next ❯

Citations

Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·R Keller
Jan 1, 1983·Journal of Clinical Immunology·S Gillis
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·T MoritaN Minato
Jan 1, 1982·Springer Seminars in Immunopathology·B Rager-Zisman, B R Bloom
Jan 1, 1986·Immunologic Research·E C LattimeO Stutman
Jan 1, 1986·Immunologic Research·J Stankova, M Rola-Pleszczynski
Jan 1, 1986·Developmental and Comparative Immunology·W C Yang, R D Schultz
Jan 1, 1984·Immunology Letters·N Schaaf-LafontaineG Degiovanni
Jan 1, 1984·International Journal of Immunopharmacology·T Kalland
Jan 1, 1988·International Journal of Immunopharmacology·G MiglioratiC Riccardi
Oct 28, 1986·Biochimica Et Biophysica Acta·M Zijlstra, C J Melief
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A KupferS J Singer
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J R MollerB R Bloom
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J HackettV Kumar
Jun 1, 1982·The Journal of Experimental Medicine·A TagliabueJ Bienenstock
Aug 1, 1982·The Journal of Experimental Medicine·G NabelH Cantor
Mar 1, 1983·The Journal of Experimental Medicine·E C LattimeO Stutman
Jan 1, 1983·Journal of Clinical Immunology·M FerrariniC E Grossi
Jun 1, 1985·The Journal of Experimental Medicine·G SchulzG Dennert
Oct 1, 1987·Journal of the American Academy of Dermatology·M GhoneumA P Kelly

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.