On the horizon: promising investigational antiretroviral agents

Current Pharmaceutical Design
Ian R McNicholl, Joan J McNicholl

Abstract

Human immunodeficiency virus (HIV) infection affects close to 40 million individuals worldwide. Since 1981 when the first case reports of individuals dying from a then rare opportunistic infection were published, twenty million people have died from this epidemic. With 3 or more antiretrovirals as the standard of care, the prevalence of single, double and triple-class resistant HIV strains has increased significantly over the last 5 years due to the tremendous replicative capacity of HIV and selective drug pressure. With greater resistance comes the need for novel and effective antiretrovirals to treat these resistant strains. The purpose of this review is to highlight the most promising agents and classes in Phase II-III drug development by assessing the clinical efficacy, pharmacology, resistance and tolerability. Three out of the four existing antiretroviral classes (nucleosides, non-nucleosides, protease inhibitors) with agents in clinical trials will be discussed such as nucleoside reverse transcriptase inhibitors (D-d4FC, SPD754), non-nucleoside reverse transcriptase inhibitors (capravirine, TMC125) and protease inhibitors (tipranavir, TMC114). In the next several years, antiretrovirals from novel pharmacologic classes wi...Continue Reading

Citations

May 16, 2008·AIDS Patient Care and STDs·Graeme MoyleChristos Tsoukas
Feb 6, 2009·Drugs·Birgitt Dau, Mark Holodniy
Oct 9, 2007·International Immunopharmacology·Yuji SaitaYasuaki Shimizu
Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dionisio A OlmedoMahabir P Gupta

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