On the hydrogen loss from protonated nucleobases after electronic excitation or collisional electron capture

European Journal of Mass Spectrometry
Jean Ann WyerH T Schmidt

Abstract

In this work, we have subjected protonated nucleobases MH(+) (M = guanine, adenine, thymine, uracil and cytosine) to a range of experiments that involve high-energy (50 keV) collision induced dissociation and electron capture induced dissociation. In the latter case, both neutralisation reionisation and charge reversal were done. For the collision induced dissociation experiments, the ions interacted with O(2). In neutral reionisation, caesium atoms were used as the target gas and the protonated nucleobases captured electrons to give neutrals. These were reionised to cations a microsecond later in collisions with O(2). In choosing Cs as the target gas, we have assured that the first electron transfer process is favourable (by about 0.1-0.8 eV depending on the base). In the case of protonated adenine, charge reversal experiments (two Cs collisions) were also carried out, with the results corroborating those from the neutralisation reionisation experiments. We find that while collisional excitation of protonated nucleobases in O(2) may lead to hydrogen loss with limited probabilities, this channel becomes dominant for electron capture events. Indeed, when sampling reionised neutrals on a microsecond timescale, we see that the rat...Continue Reading

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Citations

Apr 2, 2010·Physical Chemistry Chemical Physics : PCCP·G AravindL H Andersen
Oct 22, 2013·Physical Chemistry Chemical Physics : PCCP·Sara Øvad PedersenSteen Brøndsted Nielsen

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