PMID: 7015078Jan 1, 1981

On the immunogenicity of ribosomes and ribosomal proteins isolated from Klebsiella pneumoniae and Streptococcus pneumoniae

Microbiology and Immunology
D RobertR Fontanges

Abstract

The two pathogenic species Streptococcus pneumoniae and Klebsiella pneumoniae were used to analyze the immunogenic role of proteins in ribosomal preparations. The protective activity of ribosomes prepared from either strain and further purified by washing with high-salt concentrations, followed or not by sucrose gradient separation of the particles, was identical to that of crude unwashed ribosomes. Similarly, no substantial alteration of the level of protection was observed after treatment with the antibiotic puromycin. Therefore, the immunizing efficacy of ribosomes does not appear to be due either to the nonribosomal proteins adsorbed at the surface of organelles or to the growing polypeptide chain. It seems rather to be attributable to the structural ribosomal proteins themselves, which were indeed shown to induce alone a significant level of protection.

Citations

Mar 1, 1976·Infection and Immunity·H C Thompson, T K Eisenstein
Jan 1, 1977·Annual Review of Biochemistry·C G Kurland
Jan 1, 1976·Annual Review of Biochemistry·J A Snyder, J R McIntosh
Mar 15, 1975·FEBS Letters·Y Aharonowitz, E Z Ron
May 5, 1973·Journal of Molecular Biology·A J Cozzone, G S Stent
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M E Azzam, I D Algranati
Aug 28, 1968·Journal of Molecular Biology·E Z RonB D Davis
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·W M StanleyS Ochoa
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Apr 3, 1965·Nature·A R WILLIAMSON, R SCHWEET
Jun 1, 1970·Infection and Immunity·M R VennemanL J Berry
Jan 1, 1971·Infection and Immunity·H C Thompson, I S Snyder

Related Concepts

Variolation
Mice, Inbred BALB C
Ribosomal Proteins
Pathogenic Organism
Klebsiella pneumoniae
Puromycin Dihydrochloride
Infection by Klebsiella Pneumoniae in Conditions Classified Elsewhere and of Unspecified Site
Antigens, Bacterial
Bacterial Vaccines
Ribosomes

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