On the impact of functional imaging accuracy on selective boosting IMRT.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
Y Kim, W A Tomé

Abstract

In order to quantify the impact of loss of functional imaging sensitivity and specificity on tumor control and normal tissue toxicity for selective boosting IMRT four selective boosting scenarios were designed: SB91-81 (EUD=91Gy for the high-risk tumor subvolume and EUD=81Gy for a remaining low-risk PTV (rPTV)), SB80-74, SB90-70, and risk-adaptive optimization. For each sensitivity loss level the loss in tumor control probability (DeltaTCP) was calculated. For each specificity loss level, the increase in rectal and bladder toxicity was quantified using the radiobiological indices (equivalent uniform dose (EUD) and normal tissue complication probability (NTCP)) as well as %-volumes irradiated. The impact of loss in sensitivity on local tumor control was maximal when the prescription dose level for rPTV had the lowest value. The SB90-70 plan had a DeltaTCP=29.6%, the SB91-81 plan had a DeltaTCP=9.5%, while for risk-adaptive optimization a DeltaTCP=4.7% was found. Independent of planning technique loss in functional imaging specificity appears to have a minimal impact on the expected normal tissue toxicity, since an increase in rectal or bladder toxicity as a function of loss in specificity was not observed. Additionally, all plan...Continue Reading

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Citations

Oct 30, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·R AzzeroniR Calandrino
Jul 14, 2012·Computational and Mathematical Methods in Medicine·Nicholas Hardcastle, Wolfgang A Tome
Mar 20, 2010·Radiation Oncology·Maximilian NiyaziUte Ganswindt
May 6, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·A ArnaudG Crehange
May 1, 2010·Acta Oncologica·Yusung Kim, Wolfgang A Tomé
Mar 29, 2011·Journal of Theoretical Biology·R KeinjP Vallois
Mar 2, 2011·Seminars in Radiation Oncology·Shiva K Das, Randall K Ten Haken
Sep 15, 2014·Cancer Letters·Xiaorong ShiJinming Yu

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