On the importance of precise electrode placement for targeted transcranial electric stimulation

NeuroImage
Alexander OpitzMichael P Milham

Abstract

Transcranial electric stimulation (TES) is an increasingly popular method for non-invasive modulation of brain activity and a potential treatment for neuropsychiatric disorders. However, there are concerns about the reliability of its application because of variability in TES-induced intracranial electric fields across individuals. While realistic computational models offer can help to alleviate these concerns, their direct empirical validation is sparse, and their practical implications are not always clear. In this study, we combine direct intracranial measurements of electric fields generated by TES in surgical epilepsy patients with computational modeling. First, we directly validate the computational models and identify key parameters needed for accurate model predictions. Second, we derive practical guidelines for a reliable application of TES in terms of the precision of electrode placement needed to achieve a desired electric field distribution. Based on our results, we recommend electrode placement accuracy to be < 1 cm for a reliable application of TES across sessions.

References

Nov 1, 1996·Physics in Medicine and Biology·C GabrielE Corthout
Aug 9, 2011·Neuropsychological Rehabilitation·Walter Paulus
Mar 1, 2012·NeuroImage·D C Van EssenUNKNOWN WU-Minn HCP Consortium
Mar 19, 2014·Brain Stimulation·Sarah WiethoffJohn C Rothwell
Mar 19, 2014·Brain Stimulation·Virginia López-AlonsoMiguel Fernández-Del-Olmo
Jan 24, 2015·NeuroImage·Alexander OpitzAxel Thielscher
Apr 4, 2015·PloS One·Birk Diedenhofen, Jochen Musch
Dec 15, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J WoodsM A Nitsche
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alexander OpitzCharles E Schroeder
Jan 10, 2018·Nature Neuroscience·Rafael PolaníaChristian C Ruff

❮ Previous
Next ❯

Citations

Jul 30, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Julia BoonzaierRick M Dijkhuizen
Mar 7, 2019·Frontiers in Psychology·Anke Ninija KarabanovHartwig Roman Siebner
Mar 19, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Lucas BorrioneAndre R Brunoni
Nov 30, 2019·Nature Communications·Florian H KastenChristoph S Herrmann
Jan 31, 2020·Frontiers in Psychology·Milena Čukić
Feb 16, 2021·NeuroImage. Clinical·Egill Axfjord FridgeirssonGuido A van Wingen
Apr 15, 2020·NeuroImage·Ignacio Perez IpiñaEnzo Tagliazucchi
Dec 8, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Joachim GrossCarsten Wolters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Abhishek DattaChristopher C Pack
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
John M BernabeiAngel V Peterchev
Critical Reviews in Biomedical Engineering
Siwei BaiSocrates Dokos
© 2022 Meta ULC. All rights reserved