On the inner structure and topology of clusters in two-component lipid bilayers. Comparison of monomer and dimer Ising models

The Journal of Physical Chemistry. B
I P Sugár

Abstract

It has been shown on model and biological systems that membrane clusters can affect in-plane membrane reactions and can control biochemical reaction cascades. Clusters of two-component phospholipid bilayers have been simulated by two Ising-type lattice models: the monomer and the dimer model. In each model the plane of one layer of the bilayer is represented by a triangular lattice, each site of which is occupied by an acyl chain of either a component 1 or a component 2 lipid molecule. The dimer model assumes that pairs of acyl chains (lipid molecules) are permanently connected, forming dimers on the lattice, while in the case of the monomer model this covalent connection between acyl chains is ignored. Phase diagrams of two-component phospholipid bilayers were successfully calculated by both models. In this work, we use Monte Carlo techniques to calculate thermodynamic averages of global and local characteristics of the largest component 2 cluster (such as outer/inner perimeter, percolation, minimal linear size, and local density) and compare the results obtained by the two models. A new method is developed to characterize the inner structure of the clusters. Each point of a cluster is classified based on its shortest distance...Continue Reading

References

Oct 6, 1975·Biochimica Et Biophysica Acta·J A Op den KampL L van Deenen
Jun 30, 1992·Biochemistry·E J Bolen, J J Sando
Mar 1, 1972·Nature: New Biology·M S Bretscher
Jan 1, 1995·Molecular Membrane Biology·T E ThompsonW L Vaz
Oct 10, 1993·Biochimica Et Biophysica Acta·K JørgensenM J Zuckermann
Sep 1, 1995·Biophysical Journal·K Jørgensen, O G Mouritsen
Mar 30, 1999·Biophysical Journal·I P SugárR L Biltonen
Nov 7, 2000·Biochimica Et Biophysica Acta·J F Nagle, S Tristram-Nagle
Sep 27, 2002·Biophysical Journal·Ekaterina I Michonova-Alexova, István P Sugár
Jul 30, 2003·Biophysical Journal·Brian CannonKwan Hon Cheng
May 17, 2005·Biophysical Journal·Dino G SalinasJuan G Reyes
Jan 18, 2006·Cell Calcium·Daxin TangChristopher A Paterson
Jul 21, 2006·The Journal of Physical Chemistry. B·István P Sugár, Rodney L Biltonen

❮ Previous
Next ❯

Citations

Dec 27, 2011·Journal of the American Chemical Society·István P Sugár, Parkson L-G Chong
Jan 29, 2011·The Journal of Physical Chemistry. B·Jian DaiJuyang Huang
Jun 12, 2013·Biophysical Journal·István P SugárParkson L-G Chong
Dec 11, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Henrique S Guidi, Vera B Henriques

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.