PMID: 326688May 1, 1977Paper

On the interaction between the anti-inflammatory substance proquazone (RU 43-715) and phenprocoumone

International Journal of Clinical Pharmacology and Biopharmacy
H Vinazzer

Abstract

In a double blind study on 20 anticoagulated patients, the influence of the anti-inflammatory drug 1-isopropyl-4-phenyl-7-methyl-2 (1H) quinazolone on the degree of hypocoagulability was examined. In comparison to a placebo group, there was no statistical difference in the Quick precentage, in coagulation factors II, VII, and X, and in platelet aggregation induced by collagen and by epinephrine respectively. In addition, no increased bleeding tendency could be observed during the study.

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