On the lack of evolutionary continuity between prebiotic peptides and extant enzymes

Physical Chemistry Chemical Physics : PCCP
Luciana RaggiA Lazcano

Abstract

The significance of experiments that claim to simulate the properties of prebiotic small peptides and polypeptides as models of the polymers that may have preceded proteins is critically addressed. As discussed here, most of these experiments are based only on a small number of a larger set of amino acids that may have been present in the prebiotic environment, supported by both experimental simulations and the repertoire of organic compounds reported in carbonaceous chondrites. Model experiments with small peptides may offer some insights into the processes that contributed to generate the chemical environment leading to the emergence of informational oligomers, but not to the origin of proteins. The large body of circumstantial evidence indicating that catalytic RNA played a key role in the origin of protein synthesis during the early stages of cellular evolution implies that the emergence of the genetic code and of protein biosynthesis are no longer synonymous with the origin of life. Hence, reports on the abiotic synthesis of small catalytic peptides under potential prebiotic conditions do not provide information on the origin of triplet encoded protein biosynthesis, but in some cases may serve as models to understand the p...Continue Reading

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Citations

Oct 25, 2016·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Alberto Vázquez-SalazarAntonio Lazcano
Aug 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jay G ForsytheFacundo M Fernández
Jun 6, 2018·Chemistry : a European Journal·Ramanarayanan Krishnamurthy
Jun 8, 2017·Life·Andrew PohorilleGareth Shannon
Dec 5, 2018·Experimental Biology and Medicine·O Duhan Toparlak, Sheref S Mansy
Oct 15, 2019·Journal of Biomolecular Structure & Dynamics·J Dennis PollackDennis K Pearl
Nov 30, 2020·Acta Biotheoretica·Seymour Garte
Feb 27, 2020·Chemical Reviews·Moran Frenkel-PinterLuke J Leman
Oct 24, 2018·ACS Nano·Antonio Lazcano

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