PMID: 6976116Jan 1, 1982Paper

On the limitation of therapeutic intervention trials in ischemic heart disease: a clinician's viewpoint

The American Journal of Cardiology
A Selzer

Abstract

Therapeutic intervention trials using randomization of cases, considered the most reliable available means of evaluating effectiveness of therapy, have serious limitations. They are subject to errors in both directions: suggesting a relation when none exist, or being unable to demonstrate existing relations. When death is used as an outcome of the study, errors are most likely to occur when populations under study contain patients with widely varying prognoses, as is the case in ischemic heart disease. Furthermore, some trials pay insufficient attention to clinical facts and clinical relevance, both in designing and interpreting results of the study. The results of the Anturane reinfarction trial may have been misinterpreted on that basis. Trials dealing with comparison of medical and surgical treatment of coronary artery disease have been disappointing in their negative or inconclusive results. Another approach is needed to reinvestigate this problem, one randomizing patients with high risk subsets of coronary disease.

References

Nov 17, 1977·The New England Journal of Medicine·T C ChalmersA M Kunzler
Jun 26, 1975·The New England Journal of Medicine·B ModanM Modan
Oct 30, 1980·The New England Journal of Medicine·D L Sackett

❮ Previous
Next ❯

Citations

Aug 1, 1986·Computers and Biomedical Research, an International Journal·A MoiseB Clement
Jan 1, 1983·Journal of the American College of Cardiology·S L Weinberg
Oct 17, 2012·American Heart Journal·Ian J NeelandArshed A Quyyumi
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Aug 24, 2017·The Cochrane Database of Systematic Reviews·Joshua FeinbergJanus C Jakobsen
Jun 1, 1990·The Australian and New Zealand Journal of Psychiatry·B Draper
Sep 17, 2008·Surgical Innovation·Steven C Cunningham, Erica R H Sutton
Jan 1, 1987·Pharmacotherapy·R E Nitz, V B Fiedler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

Annals of Internal Medicine
R Prakash
The American Journal of Cardiology
W DOCK
The American Journal of Cardiology
S KRAUSE
Diseases of the Chest
S L Weinberg
© 2021 Meta ULC. All rights reserved