On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria

Theranostics
Elisa LakinOliver Schmetzer

Abstract

Chronic spontaneous urticaria (CSU) is a skin disease related to autoreactive IgE in at least a subgroup of patients. However, the nature of this autoreactive IgE remains poorly characterized. This investigation had three objectives: first, to quantity CSU autoreactive IgE; second, to recognize the patterns of CSU autoreactive IgE compared with healthy control IgE; and third, to investigate the physiochemical nature of CSU autoreactive IgE. Methods: IgE autoreactivity was assessed in sera from 7 CSU and 7 healthy individuals. Autoantigen recognition patterns were assessed using principal component analysis (PCA) and heatmap visualization. Lipophilicity was assessed using NanoOrange reagent. Results: First, although total IgE levels did not differ significantly, the autoreactive proportion of IgE of CSU patients was 62% ± 37%, 1000-fold higher than that of healthy controls 0.03% ± 0.008% (P = 0.0006). Second, CSU autoreactive IgE differed from healthy control IgE by recognizing more and different autoantigens (226 vs. 34; P = 0.01). Third, the median (with 10-90% percentiles) serum level of lipophilic IgE was 39% (38-40%) in 232 CSU patients, 1.4-fold higher than the 28% (26-29%) of 173 healthy controls (P < 0.0001). Furthermore...Continue Reading

Citations

Aug 25, 2019·Allergy·Stefanie EyerichKilian Eyerich
Feb 28, 2020·Experimental and Therapeutic Medicine·Jie-Dan PingLiang Ming
Sep 19, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ciara Jade Bansal, Amolak Singh Bansal
Jan 22, 2021·Allergy, Asthma & Immunology Research·Sabine AltrichterMarcus Maurer
Mar 25, 2021·The Journal of Allergy and Clinical Immunology·Claus BachertWilliam W Busse
Mar 31, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ian T MarkJennifer S McDonald
Sep 2, 2021·Allergology International : Official Journal of the Japanese Society of Allergology·Yuki KogaHiroaki Matsuo
Apr 1, 2020·International Archives of Allergy and Immunology·Marcus MaurerMartin Metz

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Methods Mentioned

BETA
PCA

Software Mentioned

ClustVis

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