Sep 30, 2019

On the mark: genetically engineered immunotherapies for autoimmunity

Current Opinion in Immunology
Christoph T EllebrechtAimee S Payne


Current therapies for autoimmunity cause significant morbidity and mortality. Adoptive immunotherapy using genetically engineered T cells has led to durable remissions of B cell leukemias and lymphomas, raising the question of whether the approach can be modified to target autoreactive B and T cells to induce durable remissions of autoimmunity. Here we review antigen-specific approaches to modify immune cells to treat autoimmune disease. We focus on recent studies that aim to eliminate or suppress autoimmunity by targeting the disease-causing B or T cells through their B cell receptor or T cell receptor specificities.

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Mentioned in this Paper

Immune Effector Cell
Specific antigen
Autoimmune Diseases
T-Cell Receptor
Adoptive Immunotherapy
Leukemia, B-Cell
Genetic Engineering

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