PMID: 6413207Oct 17, 1983Paper

On the mechanism by which glucocorticoids cause the activation of glycogen synthase in mouse and rat livers

European Journal of Biochemistry
M LalouxH G Hers

Abstract

The administration of glucocorticoids to mice caused within 3 h an inactivation of glycogen phosphorylase and activation of glycogen synthase in their livers. In a Sephadex filtrate of liver extract, as well as in a purified glycogen fraction obtained from treated mice, but not in the same preparations obtained from control mice, glycogen synthase was activated without previous inactivation of phosphorylase. The initial rate of synthase activation in a Sephadex filtrate was proportional to the rate of glycogen synthesis in vivo in the same animal. When the glycogen fraction was isolated in the presence of soluble starch, it could be separated from phosphorylase, phosphorylase phosphatase and synthase phosphatase. When added to a control Sephadex filtrate, this purified glycogen fraction obtained from prednisolone-treated mice relieved synthase phosphatase from inhibition by phosphorylase a, indicating that it contained a transferable 'deinhibiting factor'. This deinhibiting factor appears to be a protein and was further purified by alkyl-Sepharose or DEAE-cellulose chromatography. Another modification introduced by treatment with prednisolone was that phosphorylase phosphatase was 1.5-2-fold more active than in the liver of con...Continue Reading

References

Jan 1, 1976·Journal of Immunological Methods·A W Wheeler, P M Hatcher
Jan 1, 1979·Monographs on Endocrinology·W Stalmans, M Laloux
Jan 1, 1976·Methods in Cell Biology·P O Seglen
Jan 1, 1976·Annual Review of Biochemistry·H G Hers
Mar 7, 1977·Biochemical and Biophysical Research Communications·K KikuchiS Tsuiki
Feb 14, 1979·Biochemical and Biophysical Research Communications·M Laloux, H G Hers
Jan 1, 1971·Archives internationales de physiologie et de biochimie·W StalmansH G Hers
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Oct 6, 1972·Biochemical and Biophysical Research Communications·S A Kamath, E Rubin
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Feb 1, 1971·European Journal of Biochemistry·W StalmansH G Hers
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May 2, 1983·European Journal of Biochemistry·T S IngebritsenP Cohen
Jun 1, 1982·Molecular and Cellular Endocrinology·F VanstapelW Stalmans
Apr 1, 1961·Endocrinology·J ASHMOREG KILSHEIMER
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Jan 18, 1965·Biochemical and Biophysical Research Communications·K R HORNBROOKO H LOWRY

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Citations

Apr 15, 1996·European Journal of Biochemistry·T IidaK Tanamoto
Jan 1, 1986·Agents and Actions·H G Hers
Jan 1, 1987·Diabetes/metabolism Reviews·J H Exton
Jan 1, 1987·Diabetes/metabolism Reviews·W StalmansL Mvumbi
Aug 22, 2006·Metabolism: Clinical and Experimental·Dale S EdgertonAlan D Cherrington
May 23, 2012·Toxicologic Pathology·William J ReaganDa-Wei Gong
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·M Bollen, W Stalmans
Sep 24, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Naoki UyamaHendrik Reynaert
Apr 26, 2001·Microbiology· Tanamoto KS Azumi
Jan 21, 1985·Biochimica Et Biophysica Acta·F ErdödiP Gergely
Jul 1, 1988·Archives of Biochemistry and Biophysics·C J CiudadJ J Guinovart

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