On the mechanism of Candida spp. photoinactivation by hypericin

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Patricia López-ChicónSanti Nonell

Abstract

The photoprocesses involved in hypericin photoinactivation of three different Candida species (C. albicans, C. parapsilosis and C. krusei) have been examined. Production of singlet oxygen from the triplet state and of superoxide from both the triplet state and the semiquinone radical anion are demonstrated. Hydrogen peroxide is formed downstream of these early events. The outcome of the photodynamic treatments is dictated by the intracellular distribution of hypericin, which is different in the three species and affects the ability of hypericin to produce the different reactive oxygen species and trigger cell-death pathways. The results are in line with the previously-observed different susceptibilities of the three Candida species to hypericin photodynamic treatments.

References

Nov 1, 1991·Photochemistry and Photobiology·C S Foote
Jun 1, 1986·Photochemistry and Photobiology·N Durán, P S Song
Nov 1, 1994·Journal of Medical Microbiology·Y H Samaranayake, L P Samaranayake
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Sep 1, 1999·Free Radical Biology & Medicine·R KonakaM Inoue
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexJ E Edwards
Nov 13, 2001·Lasers in Medical Science·A B UzdenskyJ Moan
May 15, 2003·Chemical Reviews·Claude Schweitzer, Reinhard Schmidt
Jun 22, 2006·Lasers in Surgery and Medicine·Giulio JoriGabrio Roncucci
Aug 22, 2006·Current Medicinal Chemistry·Tobias KiesslichKristjan Plaetzer
Sep 21, 2006·Physical Chemistry Chemical Physics : PCCP·John W SnyderPeter R Ogilby
May 23, 2007·Planta medica·Cinzia CecchiniFilippo Maggi
Nov 27, 2007·Microbiological Research·Ryan F DonnellyMichael M Tunney
Jan 9, 2008·Photochemistry and Photobiology·Denisa KacerovskáFrantisek Smíd
Aug 30, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Ana Jiménez-BanzoSanti Nonell
Apr 2, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Thomas BreitenbachPeter R Ogilby
May 5, 2009·Free Radical Biology & Medicine·Noemi RubioRobert W Redmond
Sep 11, 2009·Molecular Pharmaceutics·Theodossis A TheodossiouPatrizia Agostinis
Jul 20, 2010·Free Radical Biology & Medicine·Xavier RagàsSanti Nonell
Feb 22, 2011·The Journal of Physical Chemistry. B·Gregor BánóPavol Miškovský
Apr 21, 2011·Current Pharmaceutical Design·Sulbha K SharmaMichael R Hamblin
Apr 28, 2011·Photochemistry and Photobiology·Minh LamElma D Baron
Dec 2, 2011·Photochemistry and Photobiology·Antonio RezustaYolanda Gilaberte

❮ Previous
Next ❯

Citations

Apr 8, 2014·Journal of Photochemistry and Photobiology. B, Biology·L MamoneA Casas
Dec 4, 2014·Journal of Dairy Science·Beatriz Rodríguez-AmigoCristiano Viappiani
Apr 24, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Vanesa Pérez-LagunaYolanda Gilaberte
Oct 27, 2015·Scientific Reports·Pietro DelcanaleCristiano Viappiani
Aug 19, 2014·Mycopathologia·Manuel Pablo Paz-CristobalAntonio Rezusta
Mar 11, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Pietro DelcanaleStefania Abbruzzetti
Sep 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alicia BeltránFrancisco Galindo
Jan 27, 2021·Photodiagnosis and Photodynamic Therapy·Julia J ShenDitte Marie L Saunte
Jul 3, 2021·International Journal of Molecular Sciences·Nikita SuvorovMikhail Grin
Apr 18, 2019·Biomacromolecules·Paolo BianchiniCristiano Viappiani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Victoria EngelhardtKristjan Plaetzer
Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Mieke RoelantsPeter A M de Witte
© 2021 Meta ULC. All rights reserved