Feb 1, 1969

On the mechanism of catalysis by vitamin B12

Proceedings of the National Academy of Sciences of the United States of America
J D Brodie

Abstract

The requirements for alkylation and binding of nitrogenous ligands to cobalamins and cobinamides suggest that the central cobalt atom can exist either approximately in the plane of the corrin or axially displaced above this plane. Distortion of the normal octahedral complex by axial displacement results when the dimethylbenzimidazole moiety of the coenzyme is prevented from coordinating with the cobalt. A general hypothesis of B(12) coenzyme catalysis that involves the potential of Co(III)-R([unk]) and Co(I)-R([unk]) transitions is proposed on the basis of these considerations.

  • References2
  • Citations8

References

Mentioned in this Paper

Wandering Spleen
Amines
Methane
Isocyanides
Vitamin B 12
Cobalamins
Vitamin B12 [EPC]
Spectrophotometry
Vitamin B12 Measurement
Abnormal Shape

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