PMID: 37416Jan 1, 1979

On the mechanism of film neoplastogenesis

Medical Hypotheses
L Libenson, M Jena


Since the inception of experimental cancer research, all theories concerning the mechanism of transformation of normal cells into neoplastic cells were constructed on the basis of the postulate that interaction of an agent and cell constituents is a condition indispensable for the occurrence of the neoplastic transformation. In the course of the past three decades, however, all attempts to uncover agents responsible for the transformations induced by chemically inert films implanted in living tissues or for the "spontaneous" transformations in vitro in cell cultures devoid of added neoplastogens, yielded consistently negative results. In regard to the neoplastogenic effect of imbedded inert films, the present article takes into consideration that films implanted in living tissues hinder the circulation of interstitial fluid in their vicinity and as a result elicit anoxia and protracted low pH gradients in the environment of the cells adjacent to the films. The effects of such protracted low pH on the metabolic activities of the surviving cells are examined and a working hypothesis is offered concerning the role of protracted environmental low pH in the mechanism of film neoplastogenesis.


May 1, 1978·Medical Hypotheses·L Libenson, M Jena
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R W Holley
Dec 25, 1953·Science·A F FITZHUGHF R EIRICH


Oct 1, 1986·Medical Hypotheses·C M MacFarlane

Related Concepts

Serum Proteins
Tumor Promoters
Neoplastic Cell Transformation
Foreign Bodies
Hydrogen-Ion Concentration
Membranes, Artificial
Neoplasms, Experimental
Plasma Albumin

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.