On the mechanism of gallium accumulation in tumours. Isolation of N-hydroxypeptides

International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
J D HerscheidA Hoekstra

Abstract

With the use of A SEP-PAK Alumina N cartridge, peptide fractions containing the hydroxamate moiety have been isolated from tumour-tissue homogenate. It is therefore postulated that N-hydroxypeptides might play a role in the accumulation of gallium-67 in tumours. The biodistribution of several 67Ga-labelled hydroxamate peptide fractions is determined. Although their biodistribution differs from that of 67Ga-citrate no enhancement in tumour accumulation is observed indicating that they do not act like tumour-specific siderophores.

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Citations

Aug 1, 1996·Nuclear Medicine and Biology·R E Weiner
Mar 19, 2014·Journal of Veterinary Pharmacology and Therapeutics·F SampieriD L Hamilton
Apr 16, 2014·Journal of Veterinary Pharmacology and Therapeutics·F SampieriD L Hamilton
May 23, 2012·Journal of Clinical Imaging Science·Ameya PuranikR D Lele

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