On the mechanism of inhibition of NADH oxidase by ubiquinone-3

Journal of Bioenergetics and Biomembranes
L LandiG Lenaz

Abstract

The combined effects of rotenone and ubiquinone-3 on the kinetics of NADH dehydrogenase and NADH oxidase have been investigated. The two inhibitors do not show additivity; on the other hand, ubiquinone-3, when preincubated with the enzyme, partially removes rotenone sensitivity. The inhibition of NADH oxidase by ubiquinone-3 is the result of at least two combined effects: the competition of the less active ubiquinone-3 with endogenous ubiquinone-10 in the acceptor site of the dehydrogenase, and a nonspecific action on the structure of complex I. The latter effect is perhaps mediated by a physical change of the phospholipid bilayer similar to that observed with agents such as butanol, perturbing lipid-protein interactions in the membrane.

References

Nov 14, 1978·Biochemical and Biophysical Research Communications·E BertoliG Lenaz
Dec 14, 1978·Biochemical and Biophysical Research Communications·G LenazT Ozawa
Jul 1, 1975·Archives of Biochemistry and Biophysics·G LenazG Parenti-Castelli
Mar 1, 1966·Archives of Biochemistry and Biophysics·L Szarkowska
Nov 22, 1966·Biochemical and Biophysical Research Communications·C HallK Folkers
Mar 11, 1968·Archives of Biochemistry and Biophysics·G LenazK Kfolkers
Nov 3, 1970·Biochimica Et Biophysica Acta·F J Ruzicka, F L Crane
Mar 5, 1971·Biochemical and Biophysical Research Communications·A CastelliK Folkers
Jan 30, 1973·Biochemistry·L YuT E King
Nov 1, 1973·The Biochemical Journal·H G Lawford, P B Garland
Feb 28, 1972·Biochimica Et Biophysica Acta·A BoverisM Wagner
Apr 1, 1981·Journal of Bioenergetics and Biomembranes·M Degli EspostiG Lenaz
Dec 22, 1980·Biochimica Et Biophysica Acta·M Gutman
Aug 1, 1981·Journal of Bioenergetics and Biomembranes·P PasqualiG Lenaz
Apr 19, 1982·Biochimica Et Biophysica Acta·Q S ZhuE C Slater

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.