PMID: 8589076Jan 1, 1995Paper

On the mechanism of nitric oxide formation upon oxidative cleavage of C = N(OH) bonds by NO-synthases and cytochromes P450

Biochimie
D MansuyB Clement

Abstract

Microsomal liver cytochromes P450 catalyze the oxidative cleavage of the C = NOH bond of many ketoximes, amidoximes and guanidoximes, and NO synthases catalyze the oxidation of N omega-hydroxy-L-arginine to citrulline and NO. All these oxidations appear to be performed either by the FE(II) O2 complex of these hemoproteins or by O2.- which is formed by its decomposition. This leads to a unifying view of the mechanisms of P450- and NOS-dependent oxidative cleavage of C = NOH bonds, the relative contribution of Fe(II) O2.- being very different in NO-synthase and cytochromes P450.

References

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Citations

Jul 12, 2002·Medicinal Research Reviews·Christos A Kontogiorgis, Dimitra Hadjipavlou-Litina
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·D Mansuy
May 29, 2002·Bioorganic & Medicinal Chemistry Letters·Tingwei CaiPeng George Wang
Jul 12, 2002·Bioorganic & Medicinal Chemistry·Ming XianPeng George Wang
Dec 1, 1996·The International Journal of Biochemistry & Cell Biology·P VetrovskyG Entlicher
Jul 10, 2004·Journal of Cardiovascular Pharmacology·Maija DambrovaJarl E S Wikberg
Sep 7, 2002·Drug Metabolism Reviews·Daniel Mansuy, Jean-Luc Boucher
Feb 25, 2006·Rapid Communications in Mass Spectrometry : RCM·Larisa OresmaaPirjo Vainiotalo
Jun 10, 2006·European Journal of Medicinal Chemistry·L OresmaaP Aulaskari
Aug 4, 2001·Nitric Oxide : Biology and Chemistry·A A CaroD A Stoyanovsky
Sep 9, 2006·Biochemical and Biophysical Research Communications·Bernd ClementSabine Heberling
Jul 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tanya SahyounRaphaël Schneider
Apr 11, 2002·Chemical Reviews·Peng George WangAdam J Janczuk
Jun 3, 2021·Biomolecules·Igor A SchepetkinMark T Quinn

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