PMID: 6169481Nov 1, 1981Paper

On the mechanism of plasma cholesterol reduction in the rat given probucol

Clinical Science
S BalasubramaniamL A Simons

Abstract

1. The effects of the cholesterol-lowering drug probucol on lipoprotein metabolism and on the key enzymes that regulate hepatic cholesterol metabolism in the rat were studied. 2. Probucol given for 2 weeks was accompanied by a significant reduction in plasma concentrations of low-density and high-density lipoproteins (LDL,HDL). The fractional catabolic rates of the apolipoproteins of HDL and LDL (apoHDL, apoLDL) were not affected by probucol, although the absolute rates of catabolism of both the apolipoproteins were significantly reduced. 3. The activities of 3-hydroxy-3-methylglutaryl-coenzyme A (CoA) reductase and cholesterol 7 alpha-mono-oxygenase, as well as the rate of hepatic sterol synthesis, were unchanged during the first 2 weeks of probucol. More prolonged probucol led to inhibition of the activity of these enzymes and reduction in sterol synthesis, although the liver cellular content of cholesterol significantly increased. 4. It is postulated that a principal mode of action of the drug is to reduce the rate of lipoprotein synthesis.

Citations

Oct 2, 2003·Biological & Pharmaceutical Bulletin·Akihiro MichiharaHiroshi Tsuji
Jul 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·B M RichardR C Pittman
Jan 1, 1988·General Pharmacology·T E StrandbergT A Miettinen
May 21, 1986·Biochimica Et Biophysica Acta·S BhattacharyaL A Simons
Apr 15, 1988·Biochimica Et Biophysica Acta·L R McLean, K A Hagaman
Feb 5, 1991·Biochimica Et Biophysica Acta·F M De La Vega, T Mendoza-Figueroa
Aug 20, 1991·Biochimica Et Biophysica Acta·B StaelsJ Auwerx

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