PMID: 5256996Mar 1, 1969Paper

On the mechanism of ribonuclease action

Proceedings of the National Academy of Sciences of the United States of America
D A Usher

Abstract

All the suggestions that have been made for the mechanism of action of ribonuclease can be classified into one or another of two classes, depending on the geometry of the displacement in the first step. Studies of related model compounds indicate that one of these two classes should include as a part of the mechanism a pentacoordinate intermediate, which undergoes pseudorotation before product can be formed. It is unlikely that the pseudorotation would be rate-limiting in the reaction of the normal substrate.

References

Jul 20, 1966·Journal of the American Chemical Society·E A Dennis, F H Westheimer
Oct 1, 1966·The Biochemical Journal·A DeavinB R Rabin
Oct 11, 1967·Journal of the American Chemical Society·D G OakenfullD A Usher

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Citations

Jan 1, 1994·Protein Science : a Publication of the Protein Society·V S deMelB F Edwards
Dec 1, 1994·Protein Science : a Publication of the Protein Society·I ZegersL Wyns
Aug 1, 1996·Protein Science : a Publication of the Protein Society·E S EberhardtR T Raines
Jan 1, 1984·Origins of Life·D A UsherK M Lo
Nov 1, 1979·Journal of Molecular Evolution·D A Usher, D Yee
Sep 6, 1976·Biochimica Et Biophysica Acta·J T Kuśmierek, B Singer
Mar 19, 2003·Bioorganic Chemistry·Ralf Stowasser, David A Usher
Feb 15, 2000·Biochimica Et Biophysica Acta·K HosonoH Takaku
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·G C RobertsO Jardetzky
Jun 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M R HarrisJ G Moffatt
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D A Usher, A H McHale
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·F EcksteinH Sternbach
Jun 1, 1993·Journal of Biomolecular Structure & Dynamics·R F SetlikR Rein
Oct 11, 1992·Nucleic Acids Research·R Kierzek
Jul 13, 2000·Protein Science : a Publication of the Protein Society·L VitaglianoL Mazzarella
Apr 10, 1991·European Journal of Biochemistry·H P GrunertU Hahn
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Erwin van DijkBertrand Séraphin
Jan 31, 1972·Biochemical and Biophysical Research Communications·F EcksteinD Suck
Sep 27, 2002·Chemistry & Biology·Ali NahviRonald R Breaker
Aug 1, 1973·Angewandte Chemie·W Saenger
Feb 16, 1972·Nature: New Biology·D A Usher
Jan 1, 1976·International Journal of Peptide and Protein Research·R R Holmes
Nov 1, 1991·International Journal of Peptide and Protein Research·Y Fujita, Y Noda
Aug 9, 2003·Journal of the American Chemical Society·Rhonda A TorresTimothy Lovell
Apr 27, 1984·Science·M MacCumber, R L Ornstein

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