PMID: 6172752Dec 11, 1981Paper

On the mechanism of the inhibition of fast axonal transport caused by exposure of frog spinal ganglia to the sodium-deficient medium

Neuroscience Letters
P A Lavoie

Abstract

Substitution of choline or sucrose for Na+ in the medium surrounding frog spinal ganglia causes an inhibition of fast axonal transport in vitro. Since an increase Ca2+ influx into neurons does occur in these media, the present experiments examined the possibility that the effect on transport is mediated by an increase in intracellular free Ca2+. The combination of the choline substitution with a 3-fold increase in extracellular Ca2+ reduced transport of [3H] proteins to 75% of control (as compared to the 63% obtained previously with choline alone), thus providing no evidence of an enhancement of choline's effect by a second factor which promotes an increase in intracellular Ca2+. When Li+ was substituted for Na+, the quantity of [3H] proteins transported fell to 40% of control despite the fact that the Li+ substitution does not modify Ca+ fluxes across the plasma membrane in neurons of the frog spinal nerve. The present findings suggest that removal of Na+ interferes with fast axonal transport by a mechanism other than an increase in intracellular Ca2+

References

Nov 1, 1969·The Journal of General Physiology·R A Sjodin, L A Beauge
Jan 1, 1981·Canadian Journal of Physiology and Pharmacology·P A Lavoie
Nov 1, 1980·Canadian Journal of Physiology and Pharmacology·M A Stout, F P Diecke

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Citations

Nov 1, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pieter Vanden BergheTerence K Smith
Dec 2, 2010·Oman Journal of Ophthalmology·Preeti Ajit PatilT S Surendran

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